Results 171 to 180 of about 17,423,018 (283)

Beyond hegemonic orders and 'happy objects': reimagining women's empowerment and intersectional leadership in the global south. [PDF]

Front Sociol
Nodipha OG, Mdhluli NI.
europepmc   +1 more source

A Generalizable Multimodal Model for Treatment‐Stratified Risk and Survival Assessment under Real‐World Constraints: A Multi‐Center Study of Colorectal Cancer

Advanced Science, EarlyView.
DAIMS is a multimodal model for treatment stratified risk and survival assessment in colorectal cancer. Training draws on pathology, genomics, and clinical reports, yet inference requires only whole slide images, and adaptation to new cohorts proceeds without target survival outcomes.
Chuangjie Cao, Zheyi Ji, Chang He, Jiying Wang, Xiaoming Luo, Junyi Liu, Xiaohu Jing, Fang Yan, Yirong Chen, Linhao Qu, Sen Yang, Le Lu, Yuming Jiang, Xiyue Wang, Chengyun Dou, Junhan Zhao   +15 more
wiley   +1 more source

How do stakeholders assess Jordan's institutional readiness for universal health coverage? An exploratory qualitative interview study in Jordan. [PDF]

BMJ Open
Alyahya MS, Abu Rumman S, Ibrahim M, Khatatbeh M.   +3 more
europepmc   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

Health worker strikes in Kenya: A symptom of governance inadequacies in a devolved health system. [PDF]

PLOS Glob Public Health
Tsofa B, Nyanchoka M, Munywoki J, Guleid F, Kagwanja N, Kanya L, Wafula F, Nzinga J.   +7 more
europepmc   +1 more source

WFS1 Deficiency Impairs PIAS4‐Associated SUMOylation and Increases Ubiquitin‐Mediated Spermatogenesis‐Related Protein Degradation Leading to Testicular Male Infertility

Advanced Science, EarlyView.
The findings establish a critical role for WFS1 in human male fertility. Mechanistically, WFS1 interacts with PIAS4 to promote the SUMOylation of key spermatogenesis‐associated proteins, which in turn competitively inhibits their K48‐linked ubiquitin‐mediated degradation during spermatogenesis.
Yunchuan Tian, Guicheng Zhao, Xiang Wang, Xinyao Tang, Gan Shen, Tiechao Ruan, Chuan Jiang, Shikun Zhao, Jincheng Zhang, Xinyue Cui, Liangchai Zhuo, Jun Ma, Yihong Yang, Tingting Lin, Ying Shen   +14 more
wiley   +1 more source

Synergistic Mechano‐Fluidic Self‐Fusion of Poly(Vinyl Alcohol)‐Modified Liquid‐Metal Particles for Post‐Treatment‐Free Soft Electronics

Advanced Science, EarlyView.
Poly(vinyl alcohol)‐modified liquid‐metal particles form conductive networks through spray‐induced self‐fusion without additional post‐treatment. Spray impact initiates oxide‐shell rupture and electrical contact, while subsequent Marangoni flow and capillary forces promote particle redistribution, neck growth, and network consolidation. This sequential
Keun‐Young Yook, Sangwon Kim, Chansoo Kim, Minkyong Kang, Yurim Lee, Mido Kim, Kijun Park, Seung Yeop Han, Seung‐Woo Cho, Gun‐Hee Lee, Kayoung Son, Hanbit Jang, Tae Young Kim, Jungmok Seo   +13 more
wiley   +1 more source

Strategic Foresight in the Federal Government: A Survey of Methods, Resources and Institutional Arrangements. [PDF]

World Futures Rev, 2018
Greenblott JM, O'Farrell T, Olson R, Burchard B.   +3 more
europepmc   +1 more source

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

Advanced Science, EarlyView.
A ROS‐responsive biomimetic nanoparticle platform co‐delivers DIDS and Mdivi‐1 to protect mitochondria and promote neural repair after intracerebral hemorrhage. By targeting LPAR1/VDAC1‐related mitochondrial dysfunction, the nanotherapy reduces oxidative injury, neuronal apoptosis, and blood‐brain barrier disruption, improving neurological recovery and
Ling Gao, Li Peng, Xiaobin Zheng, Cong Tan, Chuang Wang, Qijiang Xiong, Weiming Chen, Zhao Yang   +7 more
wiley   +1 more source

Women's family-career conflict and its implications for job performance in the South African public sector: a systematic literature review. [PDF]

Front Sociol
Madingwaneng MJ.
europepmc   +1 more source