Results 31 to 40 of about 17,418,047 (311)
Molecular Oncology, EarlyView.This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti +10 more
wiley +1 more source
Journal of Agricultural and Resource Economics, 1998 This article explores and develops three ideas: (a) that the aridity of western North America and its attendant characteristics have fundamentally shaped the work of western agricultural economists and encouraged some distinctive western contributions to
Bruce A. Weber
doaj +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Développement Durable et Territoires, 2016 This article analyzes the processes of emergence and dissemination of PES schemes in Cambodia. Our analytical framework is based on the theory of institutional change of John R. Commons.
Colas Chervier +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Understanding institutions: different paradigms, different conclusions
RAUSP: Revista de Administração da Universidade de São PauloThere is widespread agreement across the social sciences that institutions matter. Although there is widespread agreement that institutions shape the behavior of actors, there are disagreements over the extent to which they actually influence individuals
Daniel Friel
doaj +1 more source
Farvel til normalarbeidsdagen? – En studie av endring i Irland, Norge og Sverige
Tidsskrift for Samfunnsforskning, 2012 I tiden etter 1980 har ideer om fleksibilitet og deregulering preget debatter om regulering av arbeidstid. I denne artikkelen undersøkes det hvordan den regulerte normalarbeidsdagen har utviklet seg i løpet av de siste 30 år.
Heidi Nicolaisen
doaj +1 more source
Legitimacy and institutional change in international organisations: a cognitive approach
Review of International Studies, 2017 Why are some institutional designs perceived as more legitimate than others, and why is the same institutional design sometimes perceived as legitimacy-enhancing in one setting and not in another? In a world in which most international organisations (IOs)
Tobias Lenz, L. Viola
semanticscholar +1 more source
Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source