Results 51 to 60 of about 648,594 (289)

Comparison of complexity metrics for multi-institutional evaluations of treatment plans in radiotherapy

Physics and Imaging in Radiation Oncology, 2018
Background and purpose: It is known that intensity-modulated radiotherapy plans that are highly complex might be less accurate in dose calculation and treatment delivery.
Victor Hernandez, Jordi Saez, Marlies Pasler, Diego Jurado-Bruggeman, Nuria Jornet   +4 more
doaj   +1 more source

Institutional Complexity: Is It a New Direction for Institutional Research?

Issues of Economic Theory, 2023
Recently, the concept of complexity and complex systems has become quite widespread in various areas of the social sciences, including economics. This turn towards complexity also affected the study of institutions. The article is devoted to the analysis of the current directions of the complexity concept application in institutional studies in terms ...
openaire   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Navigating institutional complexities [PDF]

International Journal of Gender and Entrepreneurship, 2018
Purpose The purpose of this paper is to examine how female entrepreneurs navigate complex and challenging institutional environments. It draws on institutional theory and the concept of response strategies to institutional pressures to explore the institutional barriers that female entrepreneurs encounter and highlights the strategies women employ to ...
Langevang, Thilde, Hansen, Michael W., Rutashobya, Lettice Kinunda   +2 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Academic medical centres in the Netherlands: muddling through or radical change?

Frontiers in Public Health
IntroductionAcademic medical centres (AMCs) are designed to perform multiple tasks within a single organisation. This institutional complexity gives rise to intricate governance challenges and promotes incrementalism and muddling.MethodIn this study, we ...
Ester M. M. Cardinaal, Martijn J. H. Tjan, Patrick P. T. Jeurissen, Hubert Berden   +3 more
doaj   +1 more source

Regional Governance in Latin America: The More the Merrier? [PDF]

Revista Brasileira de Política Internacional
Latin America regional governance is characterized by institutional complexity, largely the consequence of overlapping membership and mandates. The dominant view that overlap in Latin American regional organizations is problematic warrants further ...
Cristiane Lucena Carneiro
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Balancing Accuracy and Meaning in Common-Pool Resource Theory

Ecology and Society, 2008
Common-pool resources are managed in complex environments that are amenable to understanding, analysis, and management at multiple levels. This paper develops a heuristic criterion to identify the costs and benefits of adopting various levels of analysis
Michael Cox
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source