Results 81 to 90 of about 21,039,642 (285)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Political communication, institutional cultures and linearities of organisational practice: a discourse-ethnographic approach to institutional change in the European Union

, 2011
The aim of this article is to present an approach to analysing organisational practices and identities in complex institutional spaces of the European Union (EU).
Krzyzanowski, Michal,, Michał Krzyżanowski   +1 more
core   +1 more source

Toponyms in Soviet Song Discourse (1964–1991): A Corpus-Based Study

Вопросы ономастики
This article investigates the use of toponyms (astionyms, cosmonyms, hydronyms, urbanonyms, and others) in Soviet song discourse spanning three decades (the 1960s, 1970s, and 1980s), as well as the final years of the Soviet period (1990–1991).
Anastasia Vladimirovna Kolmogorova
doaj   +1 more source

La question du dissensus au Parlement européen : le contre-discours de l’opinion minoritaire

Argumentation et Analyse du Discours, 2018
In the current system of “consensus democracy”, negotiated agreement seems to be achieved through a shared vision, a sort of “communitarian ethos” that can overcome any ideological rifts.
Rachele Raus
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Unpacking the "institutional portfolio" theoretical elements for an analysis of institutional change through objectification of resources and habitus [PDF]

The "social kill" (Fligstein, 1997 and 2001) attributed to social entrepreneurs is ont sufficiently explicit as regards their dispositions for engaging in actions of change. After placing the status of change in the context of institutionalist literature,
Viale, Thierry
core  

The discourse of institutional change in the Zambian microfinance sector [PDF]

, 2019
This paper investigates the discourse of key actors instigating institutional change in the Zambian microfinance sector. It draws from the institutional story of Zambia, which has experienced regulatory and legislative flux since drafting its first ...
Kimmitt, Jonathan, Siwale, Juliana, Siwale, J, Kimmitt, J   +3 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Institutional and Discursive Attributes of the Imperial Project in Modern Russia

Journal of Eurasian Studies
This paper aims to enhance the understanding of how the Russian imperial project has been sustained from the collapse of the Soviet Union to the present, by examining its institutional and discursive attributes and their interplay.
Irina Busygina, Alexander Tevdoy-Burmuli
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source