Results 251 to 260 of about 7,028,949 (341)

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

Pollution transfer and environmental health implications: network evolution and proximity mechanisms in the Yangtze River Delta, China. [PDF]

Front Public Health
Hu F, Yang H, Zhou X, Zhao S, Qiu L, Wei S, Wang X, Hu J, Chen Y, Hu H, Zhou H.   +10 more
europepmc   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Bridging theory and behavior for healthcare accessibility modeling: A mobility-driven revision of the E2SFCA. [PDF]

PLoS One
Kazazi AK, Li Z.
europepmc   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Digital therapy using dichoptic visual perceptual learning to improve stereopsis in children with intermittent exotropia. [PDF]

Front Digit Health
Namgung E, Ryu H, Lee JW, Lee BJ, Kang DW.   +4 more
europepmc   +1 more source

A clinically informed automated evaluation pipeline for medical image segmentation based on Medical Similarity Index. [PDF]

Phys Imaging Radiat Oncol
Fazekas S, Budai BK, Bérczi V, Maurovich Horvat P, Vizi Z.   +4 more
europepmc   +1 more source

Determinants of accuracy in frame-based stereoelectroencephalography: the role of experience, workflow, and selective use of guiding devices. [PDF]

Front Neurol
Kirchleitner SV, Quach S, Niedermeyer S, Nerlinger P, Nack A, Vollmar C, Remi J, Zimmermann H, Thon N, Schmutzer-Sondergeld M.   +9 more
europepmc   +1 more source