Results 61 to 70 of about 11,738,120 (386)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Hydrological niche separation between two coexisting shrubs in an extremely arid region

Journal of Hydrology: Regional Studies
Study region: At the southern edge of Badain Jaran Desert, China. Study focus: The mixed shrubs of Calligonum mongolicum and Nitraria sphaerocarpa are the common species in extreme arid areas.
Mingyan Fan, Hai Zhou, Lihui Tian, Heng Ren, Bing Liu, Xibin Ji, Xiangyan Feng, Qiyue Yang, Huli Gu   +8 more
doaj   +1 more source

Competitiveness of economy of Ukraine: analysis of basic factors

Вісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 2013
The article is considered and analyzed the most significant factors of competitiveness of the economy of Ukraine.
Mytsiuk S.
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The role of the research sector in ABS governance [PDF]

, 2007
The aims of this paper are to examine the renewed role of the academic sector in the innovation chain, starting from traditional knowledge and wild genetic resources and ending with a final product marketed by bio-industries; to identify changes in the ...
Brahy, Nicolas, Louafi, Selim
core  

Institutional Environments and Mayors’ Role Perceptions

, 2017
The role of mayors and their role perception may depend on the changing role of local governments, different national institutional settings, and recruitment patterns. This chapter presents an analysis of the most significant changes among European mayors in terms of their role perceptions over the past decade.
Ivan Koprić, Hlynsdottir Eva Marin, Jasmina Džinić, Enrico Borghetto   +3 more
openaire   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Implementation and design of a service-based framework to integrate personal and institutional learning environments [PDF]

, 2014
The landscape of teaching and learning has changed in recent years because of the application of Information and Communications technology. Among the most representative innovations in this regard are Learning Management Systems.
Alier Forment, Marc, Conde González, Miguel Angel, Fernández Llamas, Camino, García Peñalvo, Francisco Javier, Mayol Sarroca, Enric   +4 more
core   +2 more sources