Results 111 to 120 of about 19,856,512 (330)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

The nexus between the demand for life insurance and institutional factors in Europe: new evidence from a panel data approach

, 2017
We investigate the influence of institutional factors upon life insurance demand for 32 European countries, considering the socio-demographic and economic determinants as control variables.
S. Dragoș, C. Mare, Ingrid-Mihaela Dragotă, C. Dragoș, G. Mureșan   +4 more
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Joining the UN global compact in Spain: an institutional approach

Revista de Contabilidad: Spanish Accounting Review, 2012
The aim of this study is to analyse the incentives for Spanish organisations that have adopted a voluntary code of conduct such as the United Nations Global Compact – GC.
Ainhoa Garayar Erro, José Antonio Calvo Sánchez   +1 more
doaj  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The institutional determinants of CEO compensation: An international empirical evidence [PDF]

International Journal of Business Science and Applied Management, 2011
Corporate governance literature suggests that the relationship between CEO effort and outcomes such as firm performance is highly uncertain due to the influence of numerous organizational and environmental contingencies that are outside CEOs’ control ...
Fakhfakh, H., Singhal, P.
doaj  

Institutional factors influencing knowledge production for practice: Evidence from nonprofit studies. [PDF]

PLoS One, 2023
Ma J, Ovalle J, Wang Y.
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Determinants of successful ictal SPECT injection in phase 1 epilepsy presurgical evaluation: Findings from the pediatric epilepsy research consortium surgery database project

Epilepsia Open
Objectives The main goal of presurgical evaluation in drug‐resistant focal epilepsy is to identify a seizure onset zone (SOZ). Of the noninvasive, yet resource‐intensive tests available, ictal single‐photon emission computed tomography (SPECT) aids SOZ ...
Charuta Joshi, Rani Singh, Gang Liu, Cemal Karakas, Michael Ciliberto, Krista Eschbach, M. Scott Perry, Daniel Shrey, Tricia Morphew, Adam P. Ostendorf, Shilpa B. Reddy, Michael J. McCormack, Samir Karia, Shrishti Nangia, Lily Wong‐Kisiel, the PERC Surgery Workgroup   +15 more
doaj   +1 more source

INSTITUTIONAL EXTERNALITIES AS FACTORS OF INSTITUTIONAL CHANGES

Вестник Кемеровского государственного университета, 2013
The article states the authors' hypothesis about the ability of institutes and institutional formations to produce the external, side effects (externalities) which transforms them in one of the factors of the institutional changes.
openaire   +1 more source