ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Individual and Institutional Factors Contribute to Research Capacity Building for Early-Stage Investigators from Groups Underrepresented in Biomedical Research: A Qualitative Comparative Analysis. [PDF]
Int J Environ Res Public Health, 2023 Strekalova YAL +14 more
europepmc +1 more source
Politics, Child Mortality, and Health System Development in Tanzania and Uganda, 1995-2009. [PDF]
, 2011 Sub-Saharan African countries have diverged sharply in health status in recent years: Some have reduced premature mortality rapidly while others have made little progress, despite significant health-oriented foreign aid. This article identifies political
CROKE, KEVIN
core
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Institutional factors associated with the incidence rates of central line-associated bloodstream infection in California community hospitals. [PDF]
PLoS One, 2022 Nelson EC, Wang CH, Huang G, Kuo NW.
europepmc +1 more source
External influences on local institutions: spatial dependence and openness [PDF]
There are both empirical and theoretical arguments for the thesis that external factors have an impact on domestic institutional quality. Consequently, external factors may have large effects on domestic income via local institutions.
Gerrit Faber, Michiel Gerritse
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Institutional Factors Associated with Infection Prevention and Control Practices Globally during the Infectious Pandemics in Resource-Limited Settings. [PDF]
Vaccines (Basel), 2022 Abalkhail A, Alslamah T.
europepmc +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
The Impact of Breakthrough Innovations on the Export Performance of SMEs in Developing Countries: The Moderating Role of Institutional Factors. [PDF]
Front Psychol, 2022 Hashmi HBA +3 more
europepmc +1 more source