Results 111 to 120 of about 94,835 (290)

TRMT6‐Mediated m1A Modification of CDK9 mRNA Is a Dual‐Pronged Pathogenic Driver for HBV‐Related Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
TRMT6‐mediated m1A modification in CDK9 mRNA enhances its mRNA stability and translation efficiency, thereby increasing the protein levels of CDK9. Upregulated CDK9 promotes the progression of HCC by elevating the levels of oncogenic factors including p‐STAT3, MCL1, and BCL‐2. On the other hand, CDK9 phosphorylates TARDBP at Ser254 to activate HBV core
Rui Zhang   +12 more
wiley   +1 more source

Fifth volume of Encyclopaedia of Shevchenko Scientific Society. Naukove tovarystvo imeni Shevchenka: Entsyklopediia. Vol. 5, Dash. – Zh. Edited by Oleh Kupchyns’kyi, Oleksandra Savula. L’viv, 2022. – 700 pp.

open access: yesStudia Historiae Scientiarum
This article discusses the content of the fifth volume of the Encyclopedia of the Shevchenko Scientific Society (SSS Encyclopedia), particularly its biographical entries and institutional themes (events, facts, and phenomena from the Society’s history).
Vitalii Telvak, Viktoria Telvak
doaj   +1 more source

A note on brute vs. institutional facts

open access: yes, 2009
The paper investigates the famous Searlean distinction between "brute" and "institutional" concepts from a logical point of view. We show how the partitioning of the non-logical alphabet—e.g., into "brute" and "institutional" atoms—gives rise to interesting modal properties.
openaire   +4 more sources

A Perspective on the Applications of Triphasic Gas Storage in Electrochemical Systems

open access: yesAdvanced Science, EarlyView.
Gas storage in microporous materials positioned locally at an electrode or electrocatalyst surface enhances electrochemical processes. Abstract Microporous materials store gases under dry conditions (e.g., hydrogen or oxygen via physisorption), but in some cases microporous materials also show triphasic (e.g., in a solid|gas|liquid system) gas storage ...
Zhongkai Li   +9 more
wiley   +1 more source

Freshman facts [PDF]

open access: yes, 1974
Advice complied by Boston University School of Medicine students for incoming first year students and third or fourth year students preparing for clinical ...
Boston University School of Medicine
core  

A 3D In Vitro Model of the Human Hepatobiliary Junction

open access: yesAdvanced Science, EarlyView.
A 3D human organoid platform reconstructs the hepatobiliary junction between primary adult hepatocytes and intrahepatic cholangiocytes. These adult hepatobiliary organoids (aHBOs) support directional bile transport from canaliculi to ductule‐like structures, enable quantitative imaging of junction dynamics, and reveal cell‐type‐specific vulnerabilities
Ashley D. Westerfield   +13 more
wiley   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

open access: yesAdvanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu   +17 more
wiley   +1 more source

An institutional approach to banking reform in Eastern Europe [PDF]

open access: yes
This paper applies the arguments of institutional economics to the issue of banking system reform. Institutional reforms are of particular importance in the financial sphere because banking operations were heavily restricted under central planning and ...
Buch, Claudia M.
core  

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

open access: yesAdvanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu   +9 more
wiley   +1 more source

The EU and human rights as institutional facts in the Finnish political discourse on family reunification

open access: yes, 2019
This article analyses the Finnish political response to the refugee influx connected with the Syrian war and violent conflicts in its neighbouring states.
Linda Hyökki, Hyökki, Linda
core   +1 more source

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