Results 161 to 170 of about 94,835 (290)

Allosteric Inhibition of Polycomb Repressive Complex 2 by an EZH2‐Selective Small Molecule Inhibitor

Advanced Science, EarlyView.
The study characterizes C36, a highly selective EZH2/PRC2 inhibitor that acts via a novel allosteric mechanism. Unlike previous inhibitors, C36 inhibits EZH2/PRC2 by disrupting the allosteric communication between EZH2 and EED in a SAM‐noncompetitive manner.
Ting Cao, Dongdong Liu, Haishan Gao, Chenyang Qin, Wen Zhang, Ziyun Lu, Dongxia Tan, Yuxiu Qu, Yusong Liu, Zhiran Zou, Hongtao Yu, Wei Qi   +11 more
wiley   +1 more source

Intra-ureteric indocyanine green for ureteric visualisation in complex benign gynaecological surgery: a prospective series of 50 cases. [PDF]

Facts Views Vis Obgyn
Kim B, Mazurek J, Thing R, Kurka T, Mallick R.   +4 more
europepmc   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

V-NOSE en bloc laparoscopic hysterectomy with segmental bowel resection for deep infiltrating endometriosis (#ENZIAN C3). [PDF]

Facts Views Vis Obgyn
Gamez LAB, Cabrera Carranco R, Kondo W, Osaki JD, Vigueras Smith AF, Eugenio-Colon JD, Hernandez PSV.   +6 more
europepmc   +1 more source

Facts for patients, physicians and institutions

The Anatolian Journal of Cardiology, 2017
openaire   +2 more sources

Dynamic Single‐Binding Event Profiling With on‐Chip Microlenses for Wash‐Free Digital Biosensing

Advanced Science, EarlyView.
A microlens‐enhanced platform enables real‐time tracking and digital counting of single‐binding events using conventional bright‐field microscopy. Amplified scattering signals from gold nanoparticle labels and kinetic signature analysis allow wash‐free discrimination between specific and nonspecific interactions, while providing kinetic and mechanistic
Tingting Zhan, Lianyu Lu, Guoqiang Gu, Pengcheng Zhang, Jienan Shen, Xiaotian Tan, Wei Ye, Shi Hu, Yi Zhang, Hao Yu, Shaoqin Liu, Hairong Zheng, Hui Yang   +12 more
wiley   +1 more source

Data set: Historical Facts

, 2007
10 p. pdf file created from a six-worksheet Excel file (Excel 93-2007). Originally posted on the departmental website under "Data and Analysis" heading. Excel files have been modified (print layout only) to accommodate conversion to .pdf.
University of Oregon. Office of Institutional Research
core  

p300 Degradation by the p53‐SIAH1 Axis Relieves TBK1 Acetylation to Enhance Innate Antiviral Immunity

Advanced Science, EarlyView.
This study identifies p300 as the acetyltransferase that acetylates TBK1 and inhibits its phosphorylation. Activation of the p53‐SIAH1 axis by immune response downregulates p300 expression to sustain innate antiviral immunity. Conditional p300 knockout in alveolar epithelial cells in vivo promotes antiviral responses and suppresses virus replication ...
Huidi Yu, Zhihao Zhan, Xiaoxiang Pan, Xinyue Zhang, Penggang Liu, Jing Sun, Xiulong Xu   +6 more
wiley   +1 more source

Aboriginal and Torres Strait Islander Family Violence: facts and figures

, 2007
This resource sets out a 'facts and figures' overview of family violence impacting Aboriginal and Torres Strait Islander peoples.
Nancarrow, Heather., Schmider, Joann.
core  

"Scientific or democratic?" Bridging the implementation gap of citizen science through the study of social-symbolic objects. [PDF]

Front Public Health
Broekhuizen J, De Jong J.
europepmc   +1 more source