Results 101 to 110 of about 10,736,528 (389)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

open access: yesMolecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Explanation of Mediator Role of Dynamic Capabilities in Relational View of Competitive Advantage Strategy [PDF]

open access: yesمطالعات مدیریت راهبردی, 2017
Today, companies are seen as part of the network of relationships that they can gain competitive advantage from networks. This study has been done to analyze the role of dynamic capabilities in relation between external relations of the organization with
Esmaeil Shahtahmasbi   +2 more
doaj  

Site-level evidence-based practice accreditation: A qualitative exploration using institutional theory. [PDF]

open access: yesHum Serv Organ Manag Leadersh Gov, 2023
Hall RL   +3 more
europepmc   +1 more source

Hasn’t Institutional Theory Always Been Critical?!

open access: yes, 2019
To the provocations by Munir (in this issue) and others who call on (neo)institutional theory to become more critical, I rebut by asking: Hasn’t institutional theory always been critical?!
Gili S. Drori
semanticscholar   +1 more source

Building institutional capacity for industrial symbiosis development : a case study of an industrial symbiosis coordination network in China [PDF]

open access: yes, 2016
Recent research has examined how the concept of institutional capacity relates to the ability of organisations to deliver industrial symbiosis, and in particular how that ability itself can develop over time.
Chen, Yong   +2 more
core   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

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