Results 71 to 80 of about 5,199,711 (341)

Higher Education institutional governance reforms in the Netherlands, Portugal and Italy: A policy translation perspective addressing the homogeneous/heterogeneous dilemma

open access: yesHigher Education Quarterly, 2018
This paper addresses the homogeneous/heterogeneous dilemma regarding formal arrangements of university central governance structures. Most topical studies argue that these structures are becoming homogeneous across countries and prove it by adopting ...
Davide Donina, Sandra Hasanefendic
semanticscholar   +1 more source

Mapping trajectories of becoming: four forms of behaviour in co-housing initiatives [PDF]

open access: yes, 2016
In order learn about planning in a world increasingly characterised by resource interdependencies and a plurality of governing agencies, this paper follows the processes of becoming for two co-housing initiatives.
Boonstra, Beitske
core   +2 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

The Presence and Image of the Translator in Narrative Discourse: towards a Definition of the Translator's Ethos [PDF]

open access: yes, 2017
This paper aims at exploring the configuration of the discursive image or ethos attached to the enunciative subject assuming the responsibility for the enunciation of translated narrative (Ducrot 1984; Amossy 1999, 2009, 2012).
Spoturno, Maria Laura
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

Translation commentary re-examined in the eyes of translator educators at British universities

open access: yesJoSTrans: The Journal of Specialised Translation, 2018
Translation commentary is often used as an assessment method in translation degrees. In spite of this, relatively little attention has been paid to it empirically.
Claire Yi-yi Shih
doaj   +1 more source

Micro-strategies of Contextualization Cross-national Transfer of Socially Responsible Investment [PDF]

open access: yes
This paper examines how individuals select and mobilize local institutions when they transfer business practices across societies that are construed as dissimilar to one another.
Eva Boxenbaum, Jean-Pascal Gond
core  

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