Results 51 to 60 of about 17,420,556 (290)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Social capital, institutions and trust [PDF]

Review of Social Economy, 2006
This paper analyzes the relations between social capital, institutions and trust.These concepts are full of ambiguity and confusion.This paper attempts to dissolve some of the confusion, by distinguishing trust and control, and analyzing institutional and relational conditions of trust.It presents a tool for the analysis of the foundations of trust and
openaire   +5 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Trust as a Driver of Pro-Ecological Behaviour: The Power of Experts and Interpersonal Networks in a Low-Trust Context

Behavioral Sciences
Understanding the role of trust in shaping pro-ecological behaviour is essential for advancing effective environmental communication, particularly in societies characterized by low institutional credibility.
Velina Hristova, Kaloyan Haralampiev, Ivo Vlaev, Sonya Karabeliova   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Navigating Institutional (Dis)Trust

This chapter investigates the complex and dynamic relationship between democratic social movements and institutional trust and distrust. While movements are often grounded in social trust among members, they frequently express critical trust or outright ...
Fiket, Irena, Pudar Draško, Gazela, Vasiljević, Jelena   +2 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

الثقة المؤسسية والتخطيط التنموي بوحدات الإدارة المحلية [PDF]

Mağallaẗ Kulliyyaẗ Al-H̲idmaẗ Al-Īğtimāʿiyyaẗ Lil Dirāst wa Al-Buḥūṯ Al-Īğtimāʿiyyaẗ
ملخص الدراسة: استهدفت الدراسة تحديد العلاقة بين الثقة المؤسسية وتطبيق التخطيط التنموي بوحدات الإدارة المحلية، والتوصل إلى خطة تنموية مقترحة لتطوير وحدات الإدارة المحلية في إطار الثقة المؤسسية، وتوصلت نتائج الدراسة إلى أن مستوى الثقة المؤسسية بوحدات ...
جيهان كامل أحمد عبد الرحيم
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

How digitally-mediated interactions influence the psychological foundations of civic engagement: Evidence from urban water governance in China

Urban Governance
Citizen participation has emerged as critical to urban environmental governance, yet the micro-level mechanisms linking institutional trust to civic engagement remain underspecified.
Jingjing Cai, Xiaonan Wei
doaj   +1 more source