DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
What Makes an Economy Productive and Progressive? What Are the Needed Institutions? [PDF]
Institutions again have become the focus of the theorizing and empirical work of economists concerned with the determinants of economic growth, and of cross country differences in income levels. One central argument of this paper is that institutions and
Nelson, Richard R.
core +4 more sources
Institutional work to maintain, repair, and improve the regulatory regime: How actors respond to external challenges in the public supervision of ongoing clinical trials in the Netherlands. [PDF]
PLoS One, 2020 van Oijen JCF +3 more
europepmc +1 more source
Investigating an ‘institutional partnership’ collaborating to develop a funded project into a sustainable work-integration social enterprise (WISE) [PDF]
, 2012 This paper reports a research study that examined a partnership between a regional social enterprise development agency and a university as they collaborated to develop a work-integration social enterprise (WISE) in the UK.
Denny, Simon +2 more
core
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source
Institutional Hybridity in Networked Cultural Organizations through Boundary Work
Nordic Journal of Working Life StudiesThe article studies the impacts of the pandemic caused by the COVID-19 virus on cultural festival organizations in Finland. Festivals have been institutionalized as network organizations, which presumes boundary work with partner organizations from ...
Arja Haapakorpi +4 more
doaj +1 more source
TMC4 localizes to multiple taste cell types in the mouse taste papillae
FEBS Open Bio, EarlyView.Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava +3 more
wiley +1 more source
How institutional reforms (don’t) work in Russia
Контуры глобальных трансформаций: политика, экономика, право, 2016 The State Control Reform has signalized the new circle of the Administrative Reform in Russia. The analysis of its history shows that the declared aims of the “Dictatorship of the Law” building and the victory of the formal institutions under the ...
Maksim Vilisov
doaj
"Assessing Institutional Efficiency, Growth and Integration" [PDF]
This paper presents a new empirical methodology for evaluation of the institutional system's development in transition economies and the impact it has on economic performance.
Artur Tamazian +3 more
core