Results 61 to 70 of about 5,345,635 (309)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Special issue on “Institutional Ethnography and Comparative Social Work”

Journal of Comparative Social Work, 2015
Call for ...
Janne Iren Paulsen Breimo
doaj   +3 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Commitment or Compliance? Institutional Logics of Work Environment Management

Nordic Journal of Working Life Studies, 2017
Scholars of the work environment have pointed out how management ideas and practices inspired by a human resource approach are influencing the work environment efforts in Nordic organiza tions. In this paper, we use the ‘institutional logics’ perspective
Christian Uhrenholdt Madsen, Peter Hasle
doaj   +1 more source

Do you know what licence to publish your work under in the UOC's institutional repository, O2? [PDF]

, 2020
Aquesta infografia és una eina creada per ajudar a triar la llicència Creative Commons més adequada per a la publicació a l'O2 Repositori de la UOC.Esta infografía es una herramienta creada para ayudar a elegir la licencia Creative Commons más adecuada ...
Universitat Oberta de Catalunya. Biblioteca
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Markets Gone Hybrid: Institutional Complexity and Work Toward Market Hybridization

BAR: Brazilian Administration Review
Objective: the goal of this article is to theorize how institutional complexity and work can lead to the hybridization of markets. Methods: we draw upon a critical and reflexive analysis of institutional complexity and work, as well as the literature on ...
Leandro Bonfim, Andréa Paula Segatto
doaj   +1 more source

Enabling Institutional Messaging: TV Journalists’ Work with Interviewee Responses

Studies in Applied Linguistics & TESOL, 2019
In public broadcasting, the primary goal of interviewing an expert is to inform and educate the audience for the benefit of societal interests (Clayman, 2013).
Carol Lo, Di Yu
doaj   +1 more source

Making Institutional Repositories Work

, 2015
Quickly following what many expected to be a wholesale revolution in library practices, institutional repositories encountered unforeseen problems and a surprising lack of impact. Clunky or cumbersome interfaces, lack of perceived value and use by scholars, fear of copyright infringement, and the like tended to dampen excitement and adoption.
Callicott, Burton B., Scherer, David, Wesolek, Andrew   +2 more
openaire   +5 more sources