Results 81 to 90 of about 5,345,635 (309)
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
University Distance Education in Prisons as a Tool for Rehabilitation and Social Inclusion
Social SciencesMany countries use the deprivation of liberty as a punitive strategy to ensure citizen security. Nowadays, a rehabilitative perspective has also been included to promote social inclusion.
Gina López-Armijos +1 more
doaj +1 more source
Building digital platform ecosystems through standardization: an institutional work approach. [PDF]
Electron Mark, 2022 Costabile C, Iden J, Bygstad B.
europepmc +1 more source
Bildungsmonitoring als Institutional work
, 2022 ZusammenfassungDie Generierung und Verarbeitung von Daten und Informationen zuhanden politischer Akteure wird im Folgenden als Institutional work dargestellt. Diese Perspektive ergänzt die qualitativ-theoretische Dimensionalanalyse und schliesst sowohl an die internationale Diskussion (Bormann et al., 2018) als auch an jüngere Theorieentwicklungen an ...
openaire +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Conciliando agência e contexto na dinâmica da mudança institucional
Cadernos EBAPE.BRResumoEste ensaio apresenta estrutura analítica que busca conciliar elementos da agência e do contexto na análise de processos de mudança institucional.
Diego Maganhotto Coraiola +3 more
doaj +1 more source
"Regulating Healthcare Technologies and Medical Supplies: A Comparative Overview" [PDF]
, 1995 A complex relationship exists among EU regulations, current national practices and rules, institutional capacities to implement regulatory adjustments and the legacy of past health and regulatory policy and traditions.
Altenstetter, Christa.
core
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
IMPACT OF INSTITUTIONAL QUALITY ON HUMAN RIGHTS ABUSES IN TRANSITION ECONOMIES [PDF]
This purpose of this paper is to examine the direct effects of institutional quality on human rights abuses in transition economies. We make use of an alternative empirical approach for evaluation of institutional system’s development in transition ...
Tamazian, Artur +1 more
core +4 more sources
, 2007 Stevan Harnad, Administrative Keystroke Mandates To Record Research Output Can Serve As Open Access Mandates Too, <em> Open Access Archivangelism </em> , November 28, 2007.
openaire +1 more source