Results 251 to 260 of about 1,515,055 (315)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Repositioning Global Health: Decolonising Narratives and Practice in the African Context. [PDF]

Public Health Chall
Sarfo M, Owusuaa R.
europepmc   +1 more source

Psychology at Georgetown University: An Institutional History

, 2013
Laura Sandberg
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Expanding Horizons: Robotic Minimally Invasive Direct Coronary Artery Bypass with Left Atrial Appendage Exclusion - A Step Forward in Minimally Invasive Cardiac Surgery. [PDF]

Braz J Cardiovasc Surg
Saad A.
europepmc   +1 more source

Study on the medical behaviors of residents in Yicheng District of Zhumadian. [PDF]

Front Public Health
Nie Y, Du Y.
europepmc   +1 more source

Implementation and Clinical Application of 24-Hour Intraocular Pressure Monitoring in China: A Nationwide Survey. [PDF]

Clin Ophthalmol
Hu M, Liu T, Yao K, Wang Z, Chen M, Wang K.   +5 more
europepmc   +1 more source

Analysis of clinical research coordinator (CRC) deviation from assigned responsibilities in Sichuan, China based on empirical investigation. [PDF]

Front Med (Lausanne)
Shi S, Qin S, Yu Q.
europepmc   +1 more source

Women's health and chiropractic: Educational audit and development of core competencies. [PDF]

J Chiropr Educ
Weis CA, Brousseau D, Doucet C, Kopansky-Giles D, Bergström C, Wuytack F, Lee J, Drake-Land B, Gurule N, Pohlman KA.   +9 more
europepmc   +1 more source