Results 111 to 120 of about 6,791 (285)

Enhancing the Pharmacokinetics of Aptamers: Targeting AXL In Vivo Using a Bottlebrush Polymer‐Conjugated Aptamer

open access: yesAdvanced Healthcare Materials, EarlyView.
A phosphodiester‐backboned bottlebrush polymer (pacDNA) engineered for aptamer delivery is presented. This design enhances aptamer stability, plasma pharmacokinetics, and target engagement in vivo. In AXL‐driven cancer models, pacDNA inhibits AXL signaling and reduces tumor growth, highlighting the promise of precision polymer scaffolds in aptamer ...
Tingyu Sun   +13 more
wiley   +1 more source

A História do Radiodiagnóstico no INCA

open access: yesRevista Brasileira de Cancerologia, 2001
De forma cronológica, o artigo retrata a História do Radiodiagnóstico no INCA.
João Carlos Cabral   +2 more
doaj   +1 more source

Relatório de gestão 2013 - Instituto Sabin [PDF]

open access: yes, 2014
O presente documento consolida o relatório de ações do Instituto Sabin em 2013. Reúne todas as ações e projetos apoiados e desenvolvidos, apresentados mês a mês e disponibiliza dados de gestão com seus respectivos ...

core  

Concurrent Biocompatibility and Antimicrobial Functionality of Soft Diamond‐Like Carbon Coating for Healthcare Applications

open access: yesAdvanced Healthcare Materials, EarlyView.
Designing an engineering material that simultaneously promotes the growth of beneficial biological cells while eliminating harmful bacteria is often challenging. However, this study presents a unique carbon coating by manufacturing design capable of achieving both functions, demonstrating strong potential for various applications, including medical ...
Abdul Wasy Zia   +8 more
wiley   +1 more source

Antimicrobial Activity and Molecular Docking Studies of the Biotransformation of Diterpene Acanthoic Acid Using the Fungus Xylaria sp. [PDF]

open access: yesAntibiotics (Basel), 2023
Marinho AMDR   +12 more
europepmc   +1 more source

Geometrically Controlled WNT Activation Drives Intestinal Morphogenesis

open access: yesAdvanced Healthcare Materials, EarlyView.
Crypt‐villi‐like morphogenesis can be driven and controlled via architectural patterns in colorectal cells with the use of digital light processing printing. The resulting mini tissues exhibit budding structures and functionality, as evidenced by increased mucin expression.
Nathaniel C. Burmas   +3 more
wiley   +1 more source

Digitonin‐Loaded Nanoscale Metal–Organic Framework for Mitochondria‐Targeted Radiotherapy‐Radiodynamic Therapy and Disulfidptosis

open access: yesAdvanced Materials, EarlyView.
A mitochondria‐targeted cationic nanoscale metal organic framework shows strong radiotherapy‐radiodynamic therapy effects and selectively releases digitonin in acidic tumor microenvironments to induce disulfidptosis of cancer cells and downregulate immune checkpoints in cancer and T cells, thereby eliciting strong antitumor immunity to effectively ...
Wenyao Zhen   +7 more
wiley   +1 more source

Advances in Photonic Materials and Integrated Devices for Smart and Digital Healthcare: Bridging the Gap Between Materials and Systems

open access: yesAdvanced Materials, EarlyView.
This article summarizes significant technological advancements in materials, photonic devices, and bio‐interfaced systems, which demonstrate successful applications for impacting human healthcare via improved therapies, advanced diagnostics, and on‐skin health monitoring.
Seunghyeb Ban   +5 more
wiley   +1 more source

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