Results 111 to 120 of about 7,665 (266)

Turismo e responsabilidade social: análise do programa Berimbau da costa do Sauípe [PDF]

, 2009
[Resumen] La construcción del complejo turístico Costa do Sauípe, en Bahía (Brasil), provocó visibles cambios en las relaciones sociales, económicas y ambientales de la región al inicio de sus actividades.
Avila, Marco Aurélio, Da Cruz, Gustavo, Téllez González, Jahumara Gloria   +2 more
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Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

Fluid Forces Control Structural Remodeling of Blind‐Ended Lymphatic Microvessels

Advanced Healthcare Materials, EarlyView.
Using innovative microfluidic biofabrication with fluid mechanical insights, we recapitulated the blind‐ended microanatomy and physiological drainage properties of capillary lymphatics. Our results reveal the interrelationship between intra‐ and extraluminal regions of lymphatic vessels due to flow‐induced sprouting and morphological changes that ...
Jacob C. Holter, Shashwat S. Agarwal, Joseph W. Tinapple, Joseph M. Barlage, Travis H. Jones, Jonathan W. Song   +5 more
wiley   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

O Estado e as políticas públicas de saúde [PDF]

, 2014
Módulo 1 da capacitação de profissionais dos Núcleos de Apoio à Saúde da Família (NASF) do Mato Grosso do Sul. Tem o objetivo de que você conheça, compreenda e reflita sobre a evolução das Políticas Públicas de Saúde no Brasil até o contexto atual ...
Batiston, Adriane Pires, Santos, Mara Lisiane de Moraes dos   +1 more
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Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

CORE: Cholesterol Altered Lipid Nanoparticles for Splenic Expression of mRNA Payloads

Advanced Healthcare Materials, EarlyView.
In this paper researchers introduce CORE LNPs, a new class of lipid nanoparticles engineered to redirect mRNA expression away from the liver and into the spleen, a key immune organ. By combining chemical design with computational tools, they created cholesterol analogs that enable precise spleen‐targeted expression, providing greater applications for ...
Eshan A. Narasipura, Vincent Fung, Rachel VanKeulen‐Miller, Palas B. Tiwade, Owen S. Fenton   +4 more
wiley   +1 more source

Diferença entre perfis de brasileiros idosos no início dos anos 2000 [PDF]

Considering the importance of the Brazilian aging, this work had aimed to compare the input of the second millennium the secondary data on the elderly in four Brazilian states, where it had been done research on the subject, which are, São Paulo, Rio de ...
Fabiane Vaz, Luiz Roberto Ramos, Marina Guimarães Paes de Barros, Marília Miranda Forte Gomes, Maurício Gomes Pereira, Mônica Rebouças   +5 more
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Epistemology of bioethics : Latin American focus [PDF]

, 2009
This study is composed of two parts. In the fi rst, there is a critical analysis of the principlist type of bioethics that originated from the United States, in which the need to construct a new and broader form of epistemology for this discipline is ...
Azambuja, Letícia Erig Osório de, Garrafa, Volnei   +1 more
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