Results 241 to 250 of about 6,791 (285)

AI in Neurology: Everything, Everywhere, all at Once PART 2: Speech, Sentience, Scruples, and Service

open access: yesAnnals of Neurology, EarlyView.
Artificial intelligence (AI) applications are finding use in real‐world neurological settings. Whereas part 1 of this 3‐part review series focused on the birth of AI and its foundational principles, this part 2 review shifts gears to explore more practical aspects of neurological care.
Matthew Rizzo
wiley   +1 more source

Selective Phosphorylation of Phenols and Benzenediols by the Kinase PsiK and Variants Thereof

open access: yesAngewandte Chemie, EarlyView.
PsiK from Psilocybe cubensis phosphorylates a diverse set of substituted phenols and benzenediols beyond its native substrate. High‐throughput screening of active site mutant libraries using DESI‐MS enabled protein engineering of PsiK, further expanding its substrate scope.
Ahram Kim   +8 more
wiley   +2 more sources

Cânceres hematológicos relacionados ao trabalho identificados em pacientes do Hospital do Câncer I, no Instituto Nacional de Câncer, RJ, Brasil

open access: diamond
Christiane Soares Pereira Madeira   +8 more
openalex   +1 more source

AI in Neurology: Everything, Everywhere, All at Once Part 3: Surveillance, Synthesis, Simulation, and Systems

open access: yesAnnals of Neurology, EarlyView.
This final part 3 review builds on the practical applications discussed in part 2 and explores how artificial intelligence (AI) is transforming data management, neurological education, and neurological care across large healthcare networks and datasets. The review also highlights AI's role in real‐world and synthetic data, digital twins, and innovative
Matthew Rizzo
wiley   +1 more source

Machine Learning‐Augmented Molecular Dynamics Simulations (MD) Reveal Insights Into the Disconnect Between Affinity and Activation of ZTP Riboswitch Ligands

open access: yesAngewandte Chemie, EarlyView.
This study combines computational and experimental approaches to study how natural and synthetic small molecules interact with the ZTP riboswitch, a bacterial RNA element that regulates gene expression. Using chemical synthesis, biochemical approaches, and artificial intelligence augmented MD simulations, we analyze both ligand binding and riboswitch ...
Christopher R. Fullenkamp   +8 more
wiley   +2 more sources

Reshaping Protein‐Based Nanoparticles: Innovative Artificial Intelligence‐Driven Strategies for Structural Design and Applications

open access: yesAdvanced NanoBiomed Research, EarlyView.
Artificial Intelligence‐driven advancements in protein‐based nanoparticle design enable exceptional functionalities, overcoming traditional challenges and expanding nanomedicine applications. Nanoparticles (NPs) have become a pivotal technology in biomedical research due to their unique physicochemical properties and nanoscale size, allowing for ...
Mohammad Mahmoudi Gomari   +3 more
wiley   +1 more source

An Atomically Dispersed Photocatalyst for Undirected para‐Selective C─H Bond Functionalizations

open access: yesAngewandte Chemie, EarlyView.
This study presents an atomically dispersed recyclable heterogeneous photocatalytic method for para‐selective trifluoromethylation of electron‐deficient arenes without directing groups. Unlike previous substrate‐dependent approaches, this recyclable, atomically dispersed photocatalyst enables scalable synthesis of bioactive trifluoromethylated ...
Suman Pradhan   +16 more
wiley   +2 more sources

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