Results 61 to 70 of about 298,312 (311)

A unified modulo scheduling and register allocation technique for clustered processors [PDF]

, 2001
This work presents a modulo scheduling framework for clustered ILP processors that integrates the cluster assignment, instruction scheduling and register allocation steps in a single phase.
Codina Viñas, Josep M., González Colás, Antonio María, Sánchez Navarro, F. Jesús   +2 more
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Implementation of hyyrö’s bit-vector algorithm using advanced vector extensions 2

IJAIN (International Journal of Advances in Intelligent Informatics), 2019
The Advanced Vector Extensions 2 (AVX2) instruction set architecture was introduced by Intel’s Haswell microarchitecture that features improved processing power, wider vector registers, and a rich instruction set. This study presents an implementation of
Kyle Matthew Chan Chua, Janz Aeinstein Fauni Villamayor, Lorenzo Campos Bautista, Roger Luis Uy   +3 more
doaj   +1 more source

Graphic Library Optimization for MIPS Architecture

Elektronika ir Elektrotechnika, 2020
The aim of this paper and research was to analyse the efficiency of the compiler-generated code for the graphics library and to present results obtained by optimization for the MIPS (Million Instructions Per Second) architecture.
Teodora Novkovic, Zeljko Lukac, Petar Jovanovic, Ivan Kastelan   +3 more
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

The Task of Automatic Generation of Peephole-Optimizations: Approaches Overview, Solution of the Optimal Expansion of Managed Instructions Set Architecture

Современные информационные технологии и IT-образование, 2021
This article discusses the problem of automatic generation of peephole-optimization of the static bytecode optimizer of a virtual machine (VM) concerning the task of improving the instruction set architecture (ISA) of the VM.
Anna Antipina
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

NLU-V: A Family of Instruction Set Extensions for Efficient Symmetric Cryptography on RISC-V

Cryptography
Cryptographic primitives nowadays are not only implemented in high-performance systems but also in small-scale systems, which are increasingly powered by open-source processors, such as RISC-V.
Hakan Uzuner, Elif Bilge Kavun
doaj   +1 more source