Results 111 to 120 of about 1,949,085 (259)

Symptoms of respiratory illness in wind players and their relationship to instrument hygiene. [PDF]

Sci Rep
Breaden Madden G, Herff SA, Altenmüller E, Schuppert M, Pfeifer M, Jabusch HC.   +5 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Advanced pseudo-correlation radiometers for the Planck-LFI instrument

, 2003
The LFI (Low Frequency Instrument) on board the ESA Planck satellite is constituted by an array of radiometric detectors actively cooled at 20 K in the 30-70 GHz frequency range in the focal plane of the Planck telescope.
P. Lubin, L. Pradell, J. Tuovinen, J. Gallegos, D. Kettle, C. Lawrence, P. Jukkala, N. Roddis, A. Mediavilla, F. Villa, J. Varis, A. Mennella, R. C. Butler, G. Morgante, L. Valenziano, M. Seiffert, A. Wilkinson, R. Davis, P. Sjman, J. P. Pascual, E. Blackhurst, E. Artal, M. Bersanelli, T. Gaier, S. Levin, P. Paco, L. Fuente, N. Hughes, F. Winder, E. Martinez Gonzalez, P. Meinhold, C. Castelli, B. Aja, D. Maino, P. Kangaslahti, N. Mandolesi, T. Karttaavi   +36 more
core  

Brazilian dentists' knowledge, skills, and attitudes towards minimal intervention dentistry: development and psychometric analysis. [PDF]

Braz Oral Res
Moura RC, Perazzo MF, Leal SC, Maia LC, Massignan C.   +4 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Slide Rule Instrument

Slide rule - instrument/apparatus (Measurement category)

core  

Trends in the use of adult-specific preference-weighted health-related quality of life instruments in clinical trials over the past 50 years: a protocol for a meta-research study using deep learning-based natural language processing and large language models. [PDF]

BMJ Open
Srikhom S, Devlin N, Nghiem N, Nolte S, Vo V, Tran-Duy A.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

CARE Model Assessment for school-age children who stutter: An overview and preliminary findings. [PDF]

Front Psychol
Byrd CT, Coalson GA, Conture EG.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source