Results 81 to 90 of about 2,474,852 (293)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Flight Skill Proficiency Issues In Instrument Approach Accidents [PDF]
, 2013 Despite procedural modifications and advanced technology instrumentation, instrument approach phase accidents continue to be an issue in general aviation.
Keller, Julius C.
core +1 more source
Journal of Family and Community Medicine, 2013 Objectives: Students who perceived their learning environment positively are more likely to develop effective learning strategies, and adopt a deep learning approach.
Ghazi Alotaibi, Adel Youssef
doaj +1 more source
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Medical Education Online, 2017 Introduction: There have been a number of published studies examining the link between the effectiveness of the problem-based learning (PBL) process and students’ performance in examinations.
Jonas I. Addae +2 more
doaj +1 more source
EchoGéo, 2018 The pastoral land associations are tools of land restructuring created by the pastoral law of 1972 to propose a solution to the specific problems of the land in mountain (division, joint possessions, absentee owners).
Laurence Barthe, Corinne Eychenne
doaj +1 more source
An instrument for the multiparameter assessment of speech [PDF]
, 1999 This paper describes the development of SNORS+, a clinical, user-friendly instrument for measurement of the articulators during speech. The design criteria for the instrument were based upon a wide-ranging review of current practice and available ...
Sharp, Paul +3 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source