Results 101 to 110 of about 2,410,614 (280)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Permission-based separation logic for message-passing concurrency [PDF]

, 2010
We develop local reasoning techniques for message passing concurrent programs based on ideas from separation logics and resource usage analysis. We extend processes with permission-resources and define a reduction semantics for this extended language ...
Julian Rathke, Francalanza, Adrian, Julian Rathke B, Rathke, Julian, Adrian Francalanza A, Vladimiro Sassone, Sassone, Vladimiro, Vladimiro Sassone C, Adrian Francalanza, Schmidt, Renate A.; id_orcid, Tiu, Alwen, Schmidt, Renate A., Gregoriades, Vassilios, Postniece (previously Buisman), Linda, Renate A. Schmidt, Pattinson, Dirk, Burel, G., Gore, Rajeev, Schroder, Lutz, Renate Schmidt, Dmitry Tishkovsky, Tishkovsky, Dmitry   +21 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Construction of Mathematics Cognitive Test Instrument of Computational Thinking Model for Madrasah Aliyah Students

Nazhruna
Mathematical knowledge and computational thinking train students' ability to reason, and this is needed to be able to compete in the digital era in the future. This study aims to construct a mathematical cognitive test instrument using the computational
Muhammad Istiqlal, Edi Istiyono, Widihastuti Widihastuti, Desy Kumala Sari, Rahmat Danni, Islamiani Safitri   +5 more
doaj   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Chinese instrument music source separation with frequency-attentive multi-band neural networks

EURASIP Journal on Audio, Speech, and Music Processing
Recent progress in music source separation has been accelerated by deep learning techniques, yet most studies have focused on Western instruments and vocals, with limited attention to traditional Chinese instruments. These instruments possess distinctive
Jiaxiang Zheng, Moxi Cao, Chongbin Zhang
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Automated Microfluidic Instrument for Label-Free and High-Throughput Cell Separation

, 2018
Microfluidic technologies for cell separation were reported frequently in recent years. However, a compact microfluidic instrument enabling thoroughly automated cell separation is still rarely reported until today due to the difficult hybrid between the ...
Xinjie Zhang (4374085), Zhonghua Ni (1895701), Feifei Long (4918525), Nan Xiang (1815085), Zhixian Zhu (4918528)   +4 more
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source