Results 121 to 130 of about 506,439 (327)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Forum: Literature and Language Awareness: Using Literature to Achieve CEFR Outcomes [PDF]

, 2012
This article sets out to explore why literature (used in this article to mean poetry, plays, short stories or novels) is often a marginalised resource in EFL classrooms, even though the Common European Framework of References for Languages (CEFR ...
Carter, Ronald, Jones, Christian
core   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Glaciologist studies Greenland snow conditions and helps calibrate CryoSat instrument [PDF]

Eos, Transactions American Geophysical Union, 2011
GREENLAND—On a typically frigid mid‐July day at Summit Station, almost smack in the middle of Greenland, with the temperature hovering around −10°C, Elizabeth Morris and John Sweeny were bundled up against the cold atop their black Ski‐Doo snowmobiles, which Morris described as being similar to motorcycles on ski tracks. They drove the vehicles—without
openaire   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

SOME HELPFUL INSTRUMENTS FOR CARDIOVASCULAR SURGERY

The Journal of Thoracic and Cardiovascular Surgery, 1960
A, WELBERRY, E, SENDEROFF, I, KREEL, I D, BARONOFSKY   +3 more
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

“I can’t fall behind!” Aspirations, Technology and Becoming a Teacher in South Africa

South African Computer Journal, 2014
This article contributes a theoretical perspective on aspirations and technology in ICT4D research. The paper examines the aspirations for professional development of undergraduate pre-service teachers in South Africa, and the extent to which these are ...
Moira Bladergroen, Andy Bytheway, Lorenzo Cantoni, Wallace Chigona, Marta Pucciarelli, Amalia Georgiana Sabiescu   +5 more
doaj  

Instrumental Use of Corporate Social Responsibility and Capitalist Activism

4. Boyut Medya ve Kültürel Çalışmalar Dergisi
This study highlights how the concept of social responsibility has been transformed into corporate social responsibility (CSR), which has been detached from social responsibility both etymologically and epistemologically.
E. Sahra Öztürk
doaj   +1 more source

Virtual Instrumentation helps promote International Cooperation in Engineering Education

Journal of JSEE, 2010
As Japan faces the challenge of a declining engineering population, educators in engineering must attract, develop, and produce engineers who are ready for innovation and global cooperation in order to maintain the country’ s technical advantage. A key approach to engineering education that helps these requirements is virtual instrumentation, the use ...
openaire   +2 more sources