Results 71 to 80 of about 506,439 (327)
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Plants, People, Planet, 2022 Societal Impact Statement Trees are the backbone of many terrestrial ecosystems and provide essential benefits for people and the planet. This unique life form requires specific horticultural, management, and conservation expertise to grow and thrive ...
Jessica B. Turner‐Skoff +3 more
doaj +1 more source
Phenotip - a web-based instrument to help diagnosing fetal syndromes antenatally [PDF]
Orphanet Journal of Rare Diseases, 2014 Prenatal ultrasound can often reliably distinguish fetal anatomic anomalies, particularly in the hands of an experienced ultrasonographer. Given the large number of existing syndromes and the significant overlap in prenatal findings, antenatal differentiation for syndrome diagnosis is difficult.
Porat, S. +4 more
openaire +3 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Anthropologie & Santé, 2015 In Switzerland, assisted suicide is mainly accessible to the members of right-to-die organizations and its practice has increased in a specific legal context. The way the relatives are involved in this helping-to-die process is widely unknown.
Murielle Pott +2 more
doaj +1 more source
The Wage Elasticity of Informal Care Supply: Evidence from the Health and Retirement Study [PDF]
, 2012 This article focuses on the wage elasticity of informal care supply to elderly parents employing an instrumental variable approach to account for the fact that the wage rate is likely to be correlated with omitted variables.
Nizalova, Olena
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Case-finding instruments may help identify depression in primary care [PDF]
Evidence Based Mental Health, 2003 (2002) Gen Hos Psych 24, 225; Williams J, Pignone M, Ramirez G, Stellato C. . Identifying depression in primary care: a literature synthesis of case-finding instruments. . Jul-Aug; . : . –37 . QUESTION: How effective are case-finding instruments for identifying depression in primary care? Systematic review with meta-analysis.
openaire +2 more sources
Social Work Should Be More Proactive in Addressing the Need to Plan for End of Life [PDF]
, 2016 Few people engage in planning for life’s end and the prevalence of preparedness is particularly low in ethnic communities. As a profession, social work is well equipped to help increase planning for life’s end and the care people wish to receive. However,
Adamek, Margaret E. +3 more
core +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source