Results 101 to 110 of about 1,229,939 (300)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Ecosystems and PeopleLocal knowledge and values of coastal communities offer insights into the intricate human-nature relationships in the land-sea interface. Considering a diversity of values unveils how people perceive nature, encompassing both tangible and intangible ...
Matías Barceló +3 more
doaj +1 more source
Diagnostic Instruments for Value Congruence
Journal of Business Theory and Practice, 2014 <p><em>A comparative analysis of the studies of congruence of personal and organizational values is presented in the article. Forty publications of 1999-2012 reviewed in Emerald, Sage, APA PsycNET, Wiley, ScienceDirect, Routledge, Springer and other databases have been selected for the comparative analysis.
Jolita Vveinhardt, Evelina Gulbovaite
openaire +2 more sources
Gender Culture and Gender Gap in Employment [PDF]
This paper analyzes to what extent gender culture affects gender gap in employment. Drawing on Italian data, we measure culture by building two indices: one based on individual attitudes, as done in the existing literature; one based on firms’ attitudes.
Alessandra Casarico +2 more
core
Using bootstrap to assess uncertainties of VLBI results I. The method and image-based errors
, 2018 Very Long Baseline Interferometric (VLBI) observations of quasar jets enable one to measure many theoretically expected effects. Estimating the significance of observational findings is complicated by the correlated noise in the image plane.
Pashchenko, I. N.
core +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
The Instrumental Value Arguments for National Self-Determination [PDF]
, 2019 David Miller argues that national identity is indispensable for the successful functioning of a liberal democracy. National identity makes important contributions to liberal democratic institutions, including creating incentives for the fulfilment of ...
Lee, Hsin-wen
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
BiomedicinesBackground/Objectives: Ultraviolet radiation (UVR) induces oxidative stress in the skin by generating reactive oxygen species (ROS), which can lead to inflammatory conditions including erythema (a sign of sunburn).
Eun Ju Lee +4 more
doaj +1 more source
Instrumental intensity as a tool for post-earthquake damage assessment: validation for the strong Vrancea earthquakes of August 1986 and May 1990 [PDF]
The frequency-dependent spectrum based seismic intensity, also called instrumental intensity, is calculated basically from the integration of the square values of spectral acceleration ordinates. The values of the instrumental intensity are calibrated to
Borcia, I. S. +1 more
core +1 more source