Results 51 to 60 of about 18,258 (268)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Printing out Particle Detectors with 3D-Printers - a Potentially Transformational Advance for HEP Instrumentation [PDF]

, 2020
-This white paper suggests posing a "grand challenge" to the HEP instrumentation community, i.e. the aggressive development of additive manufacturing, also known as 3D-printing, for the production of particle detectors in collaboration with ...
M Hohlmann
core  

Advanced Instrumentation for Polyharmonic Metal Detectors [PDF]

IEEE Transactions on Magnetics, 2016
This paper describes the application of polyharmonic sinc signals in devices for metal object detection. A basic problem of conventional eddy current metal detectors (induction devices in general) lies in their limited possibilities of discrimination or identification of detected objects.
Jakub Svatos, Josef Vedral, Tomas Pospisil   +2 more
openaire   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Recent developments on Micro-Pattern Gaseous Detectors [PDF]

, 2009
Micro-Pattern Gaseous Detectors are nowadays well-established technologies and the application ranges from high-energy physics experiments (COMPASS, TOTEM, LHCb as few examples) to astrophysics, neutron detection, medical imaging.
Alfonsi, M, Alfonsi, Matteo
core   +1 more source

Instrument performance and simulation verification of the POLAR detector

Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 2017
POLAR is a new satellite-born detector aiming to measure the polarization of an unprecedented number of Gamma-Ray Bursts in the 50-500 keV energy range. The instrument, launched on-board the Tiangong-2 Chinese Space lab on the 15th of September 2016, is designed to measure the polarization of the hard X-ray flux by measuring the distribution of the ...
Kole, Merlin Reynaard, Li, Z.H., Produit, Nicolas, Tymieniecka, T., Zhang, J., Zwolinska, A., Bao, T.W., Bernasconi, Tancredi, Cadoux, Franck, Feng, M.Z., Gauvin, Neal, Hajdas, W., Kong, S.W., Li, Hancheng, Li, L., Liu, X., Marcinkowski, R., Orsi, Silvio, Pohl, Martin, Rybka, D., Sun, J.C., Song, L.M., Szabelski, J., Wang, R.J., Wang, Y.H., Wen, X., Wu, B.B., Wu, Xin, Xiao, H.L., Xiong, S.L., Zhang, L., Zhang, L.Y., Zhang, S.N., Zhang, X.F., Zhang, Y.J., Zhao, Y.   +35 more
openaire   +4 more sources