Results 61 to 70 of about 1,001,938 (228)

ATLAS Upgrade Instrumentation in the US [PDF]

open access: yes, 2013
Planned upgrades of the LHC over the next decade should allow the machine to operate at a center of mass energy of 14 TeV with instantaneous luminosities in the range 5--7e34 cm^-2 s^-1.
Brooijmans, Gustaaf   +2 more
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Electron and ion density depletions measured in the STS-3 orbiter wake [PDF]

open access: yes, 1985
The third Space Shuttle flight on Columbia carried instrumentation to measure thermal plasma density and temperature. Two separate investigations, the Plasma Diagnostics Package (PDP) and the Vehicle Charging and Potential Experiment (VCAP), carried a ...
Murphy, G. B.   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Environmental test planning, selection and standardization aids available [PDF]

open access: yes, 1968
Requirements for instrumentation, equipment, and methods to be used in conducting environmental tests on components intended for use by a wide variety of technical personnel of different educational backgrounds, experience, and interests is ...
Copeland, E. H., Foley, J. T.
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Research instrumentation for tornado electromagnetics emissions detection [PDF]

open access: yes, 1977
Instrumentation for receiving, processing, and recording HF/VHF electromagnetic emissions from severe weather activity is described. Both airborne and ground-based instrumentation units are described on system and subsystem levels. Design considerations,
Jenkins, H. H., Wilson, C. S.
core   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

Introducing instrumentation and data acquisition to mechanical engineering students using LabVIEW [PDF]

open access: yes, 2000
For several years, LabVIEW has been used within the Department of Mechanical Engineering at the University of Strathclyde as the basis for introducing the basic concepts and practice of data acquisition, and more generally, instrumentation, to ...
Oldroyd, A, Stickland, M, Strachan, P
core  

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