Results 51 to 60 of about 1,330,014 (301)

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Optimisation of Least Squares Algorithm: A Study of Frame Based Programming Techniques in Horizontal Networks [PDF]

IJMTT. V37(3):190-198 September 2016. ISSN:2231-5373, 2018
Least squares estimation, a regression technique based on minimisation of residuals, has been invaluable in bringing the best fit solutions to parameters in science and engineering. However, in dynamic environments such as in Geomatics Engineering, formation of these equations can be very challenging.
arxiv   +1 more source

Model-driven performance evaluation for service engineering [PDF]

, 2007
Service engineering and service-oriented architecture as an integration and platform technology is a recent approach to software systems integration.
Boskovic, Marko, Hasselbring, Wilhelm, Pahl, Claus   +2 more
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Genetic programming as a model induction engine

, 2000
Present day instrumentation networks already provide immense quantities of data, very little of which provides any insights into the basic physical processes that are occurring in the measured medium.
V. Babovic, M. Keijzer
semanticscholar   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

EffectiveSan: Type and Memory Error Detection using Dynamically Typed C/C++

, 2018
Low-level programming languages with weak/static type systems, such as C and C++, are vulnerable to errors relating to the misuse of memory at runtime, such as (sub-)object bounds overflows, (re)use-after-free, and type confusion. Such errors account for
Akritidis P., Duck G., Eigler F., Henning J., ISO., ISO., Jim T., Kuznetsov V., Lee B., Nagarakatte S., Serebryany K.   +10 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Perfrewrite -- Program Complexity Analysis via Source Code Instrumentation [PDF]

arXiv, 2014
Most program profiling methods output the execution time of one specific program execution, but not its computational complexity class in terms of the big-O notation. Perfrewrite is a tool based on LLVM's Clang compiler to rewrite a program such that it tracks semantic information while the program executes and uses it to guess memory usage ...
arxiv  

A Computer Assisted Program for the Selection of Band Music Relative to the Difficulty Rating of Individual Instruments [PDF]

, 1991
The purpose of the study was to develop objective grading tools in the areas of key, range, rhythm/meter, tempo, dynamic and intonation control. Each area was considered separately for 17 different instruments of the band. The study included the development of a computer program capable of permitting a band director to objectively analyze the strengths
openaire   +3 more sources