Results 121 to 130 of about 498,256 (338)

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Research progress of IGF-1 and IGFBP-3 in type 2 diabetes and its microvascular complications

生物医学转化
The prevalence of type 2 diabetes mellitus (T2DM) and its microvascular complications is increasing year by year, posing a serious threat to human health and greatly increasing the socioeconomic burden.
Huang Shuting, Yang Yang
doaj   +1 more source

Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity [PDF]

, 2015
The nuclear factor κB (NF-κB) pathway is a master regulator of inflammatory processes and is implicated in insulin resistance and pancreatic β cell dysfunction in the metabolic syndrome.
Brink, Robert, Cantley, James, Grey, Shane T., Hesselson, Daniel, Koay, Yen Chin, Loudovaris, Tom, Malle, Elisabeth K., McAlpine, Shelli R., Tan, Bernice M., Villanueva, Jeanette E., Walters, Stacey N., Wu, Jianmin, Zammit, Nathan W.   +12 more
core   +4 more sources

Oral Dosed Organo‐Silica Nanoparticles Restore Glucose Homeostasis and β‐Cell Function in Diabetes Rats

Advanced Functional Materials, EarlyView.
An oral nanoplatform, MOP@T@D, which can maintain glucose homeostasis and restore islet β cells in diabetic rats is developed. It achieves efficient intestinal absorption and liver‐targeted delivery. The nanoparticle disintegrates only in response to hyperglycemia to release insulin on demand and provides antioxidant protection through selenoprotein ...
Chenxiao Chu, Mingli Wei, Che Bian, Xiaoshuang Bi, Yaxin Deng, Peifu Xiao, Jiansong Zhao, Yuying Wang, Haibing He, Jingxin Gou, Tian Yin, Xing Tang, Li Yang, Hongbo Zhang, Yu Zhang   +14 more
wiley   +1 more source

Serum Biomarkers for Hepatocellular Carcinoma (Short Review) [PDF]

, 2009
Hepatocellular carcinoma (HCC) atau kanker hati adalah salah satu dari kanker yang paling umum dan menjadi penyebab utama kematian di negara-negara Asia. HCC biasanya berkembang pada pasien dengan penyakit hati kronis dan sirosis.
Bachtiar, I. (Indra), Tai, S. (Susan), Utama, A. (Andi)   +2 more
core  

A Heparin‐Functionalized Scaffold with HB‐EGF Immobilization for Tissue Engineering

Advanced Healthcare Materials, EarlyView.
In this study, a heparin‐functionalized scaffold is designed for bio‐mimicking growth factors reservoir function of extracellular matrix. Due to the presence of heparin‐binding domain, heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is effectively and spatially captured by heparin‐functionalized scaffold.
Bowu Peng, Huajian Chen, Chengyu Lu, Tianjiao Zeng, Man Wang, Toru Yoshitomi, Naoki Kawazoe, Yingnan Yang, Guoping Chen   +8 more
wiley   +1 more source

Hyaluronan and Hyaluronidase, which is better for embryo development? [PDF]

, 2016
Our aim was to examine size-specific effects of Hyaluronan (HA) on preimplantation embryo development. We investigated the effects of Hyalovet (HA, 500–750 kDa; the size produced by HA synthase-3, which is abundant in the oviduct), or HA treated with ...
Ali A. Fouladi-Nashta, Aruffo, Aviles, Bastow, Bergqvist, Block, Bourguignon, Choudhary, Csoka, Dicker, Fenwick, Fouladi-Nashta, Furnus, Furnus, Georgiou, Hahnel, Hess, Kabir A. Raheem, Lane, Laurent, Lesley, Lloyd, Marei, Marei, Mariani, Matwee, Mazdak Salavati, Mehta, Mohey-Elsaeed, Muhammad Khalid, Neira, Oesterreicher, Ohno-Nakahara, Pandey, Pushpakumara, Raheem, Robinson, Rozen, Russell, Ryan, Saliba, Schmidt, Seytanoglu, Stern, Stevenson, Tienthai, Tina Tremaine, Tombolan, Toole, Torner, Ulbrich, Waleed F.A. Marei, Wang, Wathes, Watson, Way, Weigel, Xu, Yevdokimova, Yoon   +59 more
core   +2 more sources

Platelet Lysate–Enriched Human Induced Pluripotent Stem Cell–Derived Chondrocyte Sheets for Bone Defect Repair via Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human iPSC‐derived hypertrophic chondrocyte sheet promotes bone regeneration. Abstract Bone defects are a major clinical challenge, primarily owing to the limited self‐healing capacity of bones and the high risk of complications associated with conventional treatment strategies.
Yiwei Chen, Jiali Lin, Jiapeng Li, Yiwei Hu, Jiansen Su, Yu Miao, Lanlan Wang, Qian Tang, Changqing Zhang, Junhui Yin   +9 more
wiley   +1 more source

Mesenchymal Stem Cell‐Derived Apoptotic Micro‐Vesicles Repaired Sciatic Nerve Defect by Regulating Early Inflammatory Microenvironment and Promoting Angiogenesis

Advanced Healthcare Materials, EarlyView.
HUCMSC‐Apo‐mvs enhance peripheral nerve repair by modulating the inflammatory microenvironment (IME), primarily through coordinated actions on three functional cells. They recruit macrophages and promote their polarization from pro‐inflammatory M1 to anti‐inflammatory M2 phenotypes, increasing secretion of IL‐10 and VEGF.
Haolin Liu, Yiben Ouyang, Bo Wang, Xiaochun Zhang, Yanjun Guan, Ruichao He, Yuhui Cui, Junli Wang, Qianru Yao, Yixiao Tan, Xiwei Peng, Xing Xiong, Sice Wang, Dongdong Li, Haofeng Cheng, Tianqi Su, Xiaoyang Fu, Jinjuan Zhao, Mingqian Yu, Yi Wang, Jiang Peng, Yu Wang   +21 more
wiley   +1 more source

Association of IGF-1 and IGFBP-3 with metabolic abnormalities among children and adolescents

Frontiers in Endocrinology
Background and ObjectiveInsulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) play roles in growth and development, but their association with metabolic abnormalities in children and adolescents remains unclear ...
Zhenghao Zhao, Yuanyuan Ma, Xinyi Zhang, Xiaoxiao Liu, Yang Li, Zhongze Fang, Zhongze Fang, Zhongze Fang, Rongxiu Zheng, Jing Li, Jing Li, Jing Li   +11 more
doaj   +1 more source