Results 271 to 280 of about 411,109 (307)

Insulin-Like Growth Factor Binding Protein-2: Contributions of the C-Terminal Domain to Insulin-Like Growth Factor-1 Binding

Molecular Pharmacology, 2006
Signaling by the insulin-like growth factor (IGF)-1 receptor (IGF-1R) has been implicated in the promotion and aggressiveness of breast, prostate, colorectal, and lung cancers. The IGF binding proteins (IGFBPs) represent a class of natural IGF antagonists that bind to and sequester IGF-1/2 from the IGF-1R, making them attractive candidates as ...
Megan M, Kibbey, Mark J, Jameson, Erin M, Eaton, Steven A, Rosenzweig   +3 more
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Insulin-like Growth Factor 1, Insulin-like Growth Factor-Binding Protein 3, and Testicular Germ-Cell Tumor Risk

American Journal of Epidemiology, 2008
Studies have consistently shown that taller men are at increased risk of testicular germ-cell tumors. Thus, it is plausible that factors associated with height may also influence risk of these tumors. The authors examined associations between testicular germ-cell tumor risk and circulating concentrations of insulin-like growth factor 1 (IGF-1) and ...
Victoria M, Chia, Sabah M, Quraishi, Barry I, Graubard, Mark V, Rubertone, Ralph L, Erickson, Frank Z, Stanczyk, Katherine A, McGlynn   +6 more
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Elevated Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-2 in Malignant Pleural Effusion

Acta Oncologica, 2002
Insulin-like growth factor-1 (IGF-1) and its binding proteins (IGFBPs) are produced by many tissues and are present in serum and other biological fluids. Alterations in sera of IGF-1 and 2 and IGFBPs were demonstrated in patients with malignancy, infection and other diseases causing pleural effusion.
David, Olchovsky, Ilan, Shimon, Iris, Goldberg, Tiberiu, Shulimzon, Aharon, Lubetsky, Alon, Yellin, Clara, Pariente, Avraham, Karasik, Hannah, Kanety   +8 more
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Insulin-like growth factor-1 and insulin-like growth factor-binding protein-3 in women with premenstrual syndrome

Fertility and Sterility, 1998
To determine whether women with premenstrual syndrome (PMS) have aberrations of the GH axis as has been demonstrated in individuals with depression.Prospective trial.Department of Obstetrics and Gynecology, University of California, Los Angeles.After prospective screening, 32 healthy women with PMS and 32 asymptomatic controls completed the study ...
A J, Rapkin, M, Cedars, M, Morgan, L, Goldman   +3 more
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Somatomedin-1 binding protein-3

BioDrugs, 2003
Somatomedin-1 binding protein-3 [insulin-like growth factor-1 binding protein-3, SomatoKine] is a recombinant complex of insulin-like growth factor-1 (rhIGF-1) and binding protein-3 (IGFBP-3), which is the major circulating somatomedin (insulin-like growth factor) binding protein; binding protein-3 regulates the delivery of somatomedin-1 to target ...
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Insulin-Like Growth Factor Binding Protein-1

1994
IGFBP-I is a 25.3 kDa protein and is one of 6 structurally related proteins which bind and modulate the bioactivity of IGF-I and IGF-II. It is synthesized primarily in the liver and decidualized uterine endometrium, and is distributed primarily in the intravascular space and lymph.
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INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 MODULATES BLOOD GLUCOSE LEVELS

Endocrinology, 1991
We have determined the consequences of insulin-like growth factor-binding protein-1 (IGFBP-1) administration alone and in combination with insulin-like growth factor-I (IGF-I). Human recombinant IGF-I, infused as a bolus into male Wistar rats, induced a fall in plasma glucose to 72 +/- 3% of baseline 15 min after injection.
M S, Lewitt, G S, Denyer, G J, Cooney, R C, Baxter   +3 more
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Testosterone increases insulin-like growth factor-1 and insulin-like growth factor-binding protein.

Annals of clinical and laboratory science, 1995
Growth of the male external genitalia is primarily regulated by androgens; however, several observations suggest growth hormone (GH) or a GH dependent factor, such as insulin-like growth factor-1 (IGF-1), might also be involved. It is hypothesized that testosterone (T) might induce the synthesis of IGF-1 or IGF-binding protein (IGF-BP) which could ...
W S, Ashton, B M, Degnan, A, Daniel, G L, Francis   +3 more
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Insulin‐like growth factor binding protein‐1 in female reproductive functions

International Journal of Gynecology & Obstetrics, 1992
AbstractMultiple lines of evidence suggest that growth factors and related proteins are involved in the regulation of reproductive functions. It appears that hormones and local regulators control each other's production and action. Thus, the same regulatory factor may have different effects depending on the context in which it acts. Insulin‐like growth
E M, Rutanen, M, Seppälä
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Insulin-Dependent Regulation of Insulin-Like Growth Factor-Binding Protein-1*

The Journal of Clinical Endocrinology & Metabolism, 1990
In previous studies it has been determined that food ingestion or glucose infusion suppresses serum insulin-like growth factor-binding protein-1 (IGFBP-1) concentrations in normal subjects. It has not been determined, however, whether glucose-dependent suppression is due to enhancement of insulin-stimulated glucose transport, to some other insulin ...
D K, Snyder, D R, Clemmons
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