Results 101 to 110 of about 16,467 (249)
Advanced Science, EarlyView.Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu +5 more
wiley +1 more source
An integer linear programming for a comprehensive reverse supply chain
Cogent Engineering, 2014 Reverse supply chain is a cycle of recovery for the products and materials used by the customers but can be returned to the chain performing some operations.
Hoda Mahmoudi, Hamed Fazlollahtabar
doaj +1 more source
Advanced Science, EarlyView.SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley +1 more source
Linear Programming and Integer Linear Programming in Bioinformatics.
, 2015 A wide range of important problems related to bioinformatics and computational biology are optimization problems asking for a solution that minimizes or maximizes a certain objective function. Often, these problems are combinatorial optimization problems that can be formulated as integer linear programs. While for some of these problems polynomial time
openaire +2 more sources
CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning
Advanced Science, EarlyView.CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang +11 more
wiley +1 more source
Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization
Advanced Science, EarlyView.A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley +1 more source
Real‐Time Investigation of Interfacial Evolution in Electrochemical Energy Storage Systems via EQCM
Advanced Science, EarlyView.Understanding the electrode/electrolyte interface (EEI) is crucial for supercapacitors and batteries. EQCM, by enabling real‐time monitoring of mass changes during charge–discharge cycles, has evolved into a vital method for analysis of EEI. It provides important insights into charge‐storage mechanisms, electrode structural evolution, ion‐transfer ...
Zixuan Wang, Situo Cheng, Guang Feng
wiley +1 more source
A safety framework for flow decomposition problems via integer linear programming. [PDF]
Bioinformatics, 2023 Dias FHC +4 more
europepmc +1 more source
Charge‐Transfer‐Mediated Boron Magneto‐Ionics: Towards Voltage‐Driven Multi‐Ion Transport
Advanced Science, EarlyView.This study demonstrates voltage‐driven multi‐ion transport in FeBO systems, revealing simultaneous motion of B, Fe, and O ions enabled by charge‐transfer effects. By tuning oxidation states through oxygen incorporation, we achieve a transition from electrostatic‐like to electrochemical magneto‐ionic behavior. The findings establish boron magneto‐ionics,
Zheng Ma +15 more
wiley +1 more source
Surrogate "Level-Based" Lagrangian Relaxation for mixed-integer linear programming. [PDF]
Sci Rep, 2022 Bragin MA, Tucker EL.
europepmc +1 more source