Results 111 to 120 of about 48,063 (294)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Electric network and Hirota type 4-simplex maps

Journal of High Energy Physics
Bazhanov-Stroganov (4-simplex) maps are set-theoretical solutions to the 4-simplex equation, namely the fourth member of the family of n-simplex equations, which are fundamental equations of mathematical physics.
S. Konstantinou-Rizos
doaj   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky, Cara Joyce, H. Jeremy Bockholt, Paul A. Rudnick, William H. Adams, Fiona McAllister, Justin W. Smock, Michael A. Newton, Jane S. Paulsen   +8 more
wiley   +1 more source

Algebraic Structures and Eigenstates for Integrable Collective Field Theories

, 1992
Conditions for the construction of polynomial eigen--operators for the Hamiltonian of collective string field theories are explored. Such eigen--operators arise for only one monomial potential $v(x) = \mu x^2$ in the collective field theory. They form a $
A. Jevicki, A. Jevicki, A.M. Perelomov, Antal Jevicki, C. Pope, C. Pope, D. Gross, D. Gross, D. Gross, D. Gross, D. Minic, E. Brézin, E. Brézin, E. Witten, E. Witten, E.K. Sklynin, F. Calogero, G. Moore, G. Moore, I. Bakas, I. Bakas, I. Klebanov, J. Avan, J. Avan, J. Avan, J. Liouville, J. Polchinski, Jean Avan, K. Demeterfi, K. Demeterfi, M. Douglas, M. Jimbo, M. Jimbo, M. Nomura, M.A. Olshanetsky, P. DiFrancesco, S.R. Das, V. Alfaro de, V.G. Drinfel'd, V.I. Arnol'd   +39 more
core   +2 more sources

Path integral quantization of parametrized field theory [PDF]

Physical Review D, 2004
Free scalar field theory on a flat spacetime can be cast into a generally covariant form known as parametrised field theory in which the action is a functional of the scalar field as well as the embedding variables which describe arbitrary, in general curved, foliations of the flat spacetime.
openaire   +2 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Conservation laws in Skyrme-type models

, 2008
The zero curvature representation of Zakharov and Shabat has been generalized recently to higher dimensions and has been used to construct non-linear field theories which either are integrable or contain integrable submodels.
A. Wereszczyński, Attal R., C. Adam, J. Sánchez-Guillén   +3 more
core   +1 more source

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Local charges in involution and hierarchies in integrable sigma-models

Journal of High Energy Physics, 2017
Integrable σ-models, such as the principal chiral model, ℤ T $$ {\mathbb{Z}}_T $$ -coset models for T ∈ ℤ ≥ 2 $$ T\in {\mathbb{Z}}_{\ge 2} $$ and their various integrable deformations, are examples of non-ultralocal integrable field theories described by
S. Lacroix, M. Magro, B. Vicedo
doaj   +1 more source