Results 101 to 110 of about 8,648 (287)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Generalized Hirota bilinear identity and integrable q-difference and lattice hierarchies.

, 1995
Hirota bilinear identity for Cauchy-Baker-Akhieser (CBA) kernel is introduced as a basic tool to construct integrable hierarchies containing lattice and q-difference times.
Bogdanov, Bogdanov, Grinevich, L.V. Bogdanov, Miwa, Segal, Zakharov, Zakharov   +7 more
core   +1 more source

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron, Nicholas E. Clifton, Daniel Cabezas de la Fuente, Peter Holmans, Nicholas J. Bray, Kathryn J. Peall   +5 more
wiley   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Electric network and Hirota type 4-simplex maps

Journal of High Energy Physics
Bazhanov-Stroganov (4-simplex) maps are set-theoretical solutions to the 4-simplex equation, namely the fourth member of the family of n-simplex equations, which are fundamental equations of mathematical physics.
S. Konstantinou-Rizos
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Functional representations of integrable hierarchies

, 2006
We consider a general framework for integrable hierarchies in Lax form and derive certain universal equations from which `functional representations' of particular hierarchies (like KP, discrete KP, mKP, AKNS), i.e.
Ablowitz M J, Aristophanes Dimakis, Bogdanov L V, Bogdanov L V, Bogdanov L V Konopelchenko B G Martinez Alonso L, Błaszak M, Curtright T, Date E, Dickey L A, Dickey L A Strampp W, Dimakis A, Dimakis A, Dimakis A Müller-Hoissen F, Dubrovsky V G, Ebrahimi-Fard K, Folkert Müller-Hoissen, Gesztesy F, Haine L, Hasse H, Hirota R, Iliev P, Kupershmidt B A, Kupershmidt B A, Macdonald I G, Mason L J, Matsumura H, Nijhoff F W, Ohta Y, Pritula G M, Rogers C, Ueno K, Vekslerchik V E, Vekslerchik V E, Vekslerchik V E, Wilson G   +34 more
core   +3 more sources

Associativity equations in dispersionless integrable hierarchies

Physics Letters B, 2001
We discuss the origin of the associativity (WDVV) equations in the context of quasiclassical or Whitham hierarchies. The associativity equations are shown to be encoded in the dispersionless limit of the Hirota equations for KP and Toda hierarchies. We show, therefore, that any tau-function of dispersionless KP or Toda hierarchy provides a solution to ...
Boyarsky, A.M., Marshakov, A., Ruchayskiy, O., Wiegmann, P., Zabrodin, A.   +4 more
openaire   +3 more sources

Diffusion Spectrum Imaging Maps Early Axonal Loss and a Unique Progressive Signal in Neuronal Intranuclear Inclusion Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To delineate specific in vivo white matter pathology in neuronal intranuclear inclusion disease (NIID) using diffusion spectrum imaging (DSI) and define its clinical relevance. Methods DSI was performed on 42 NIID patients and 38 matched controls.
Kaiyan Jiang, Yixiu Pei, Xiaobao Hu, Ying Xiong, Fang Wang, Yanyan Yu, Min Zhu, Dandan Tan, Meihong Zhou, Daojun Hong, Fuqing Zhou   +10 more
wiley   +1 more source