Results 101 to 110 of about 25,165,823 (318)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Integrable versus Non-Integrable Spin Chain Impurity Models
, 1993 Recent renormalization group studies of impurities in spin-1/2 chains appear to be inconsistent with Bethe ansatz results for a special integrable model.
Affleck I +9 more
core +2 more sources
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Molecular Oncology, Volume 19, Issue 12, Page 3613-3633, December 2025.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Bi-Hamiltonian representation of St\"{a}ckel systems
, 2009 It is shown that a linear separation relations are fundamental objects for integration by quadratures of St\"{a}ckel separable Liouville integrable systems (the so-called St\"{a}ckel systems).
B. A. Dubrovin +4 more
core +2 more sources
Molecular Oncology, Volume 19, Issue 12, Page 3548-3577, December 2025.This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh +8 more
wiley +1 more source
Bidifferential Calculus, Matrix SIT and Sine-Gordon Equations
Acta Polytechnica, 2011 We express a matrix version of the self-induced transparency (SIT) equations in the bidifferential calculus framework. An infinite family of exact solutions is then obtained by application of a general result that generates exact solutions from solutions
A. Dimakis +2 more
doaj
New integrable problems in a rigid body dynamics with cubic integral in velocities
Results in Physics, 2018 We introduce a new family of the 2D integrable mechanical system possessing an additional integral of the third degree in velocities. This system contains 20 arbitrary parameters.
A.A. Elmandouh
doaj +1 more source
Eigenstate thermalization within isolated spin-chain systems
, 2013 The thermalization phenomenon and many-body quantum statistical properties are studied on the example of several observables in isolated spin-chain systems, both integrable and generic non-integrable ones.
G. D. Mahan +3 more
core +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source