Results 101 to 110 of about 24,425,209 (308)

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

open access: yesMolecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma   +9 more
wiley   +1 more source

A 2+1-Dimensional Non-Isothermal Magnetogasdynamic System. Hamiltonian-Ermakov Integrable Reduction

open access: yesSymmetry, Integrability and Geometry: Methods and Applications, 2012
A 2+1-dimensional anisentropic magnetogasdynamic system with a polytropic gas law is shown to admit an integrable elliptic vortex reduction when γ=2 to a nonlinear dynamical subsystem with underlying integrable Hamiltonian-Ermakov structure.
Hongli An, Colin Rogers
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

open access: yesMolecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu   +12 more
wiley   +1 more source

Reduction of infinite dimensional equations

open access: yesElectronic Journal of Differential Equations, 2006
In this paper, we use the general Legendre transformation to show the infinite dimensional integrable equations can be reduced to a finite dimensional integrable Hamiltonian system on an invariant set under the flow of the integrable equations.
Zhongding Li, Taixi Xu
doaj  

Landscape of BRAF transcript variants in human cancer

open access: yesMolecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda   +5 more
wiley   +1 more source

Topological Invariant of Integrable Hamiltonian System on Cone Located in a Potential Field

open access: yesپژوهش‌های ریاضی, 2020
The theory of topological classification of integrable Hamiltonian systems with two degrees of freedom due to Fomenko and his school‎. ‎On the basis of this theory we give a topological Liouville classification of the integrable Hamiltonian systems with ...
Ghorbanali Haghiighatdoost,
doaj  

ON ONE NONLINEAR INTEGRABLE MODEL OF WAVE INTERACTION

open access: yesИзвестия высших учебных заведений. Поволжский регион: Физико-математические науки, 2020
Background. In this work, the functional method is applied to a first-order matrix system and the corresponding equations of wave dynamics are derived.
V. M. Zhuravlev
doaj   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

open access: yesMolecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh   +8 more
wiley   +1 more source

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