Results 141 to 150 of about 780,879 (337)

Existence Results for Nonlinear Fractional Problems with Non-Homogeneous Integral Boundary Conditions

, 2020
Alberto Cabada, Om Kalthoum Wanassi
openalex   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Positive solutions for boundary-value problems with integral boundary conditions on infinite intervals

Electronic Journal of Differential Equations, 2012
In this article, we consider the existence of positive solutions for a class of boundary value problems with integral boundary conditions on infinite intervals $$displaylines{ (varphi_{p}(x'(t)))'+phi(t)f(t,x(t),x'(t))=0, quad 0<t<+infty,cr x ...
Changlong Yu, Jufang Wang, Yanping Guo, Huixian Wei   +3 more
doaj  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Symmetric positive solutions for $\phi$-Laplacian boundary-value problems with integral boundary conditions

Electronic Journal of Differential Equations, 2013
In this article, we study the existence, multiplicity, and nonexistence of symmetric positive solutions for a class of four-order integral boundary value problems with $\phi$-Laplacian operator.
Wengui Yang
doaj  

Existence results for higher order fractional differential inclusions with multi-strip fractional integral boundary conditions

, 2013
Bashir Ahmad, Sotiris K. Ntouyas
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Maximum Principle in the Optimal Control Problems for Systems with Integral Boundary Conditions and Its Extension [PDF]

, 2013
Ali Safari, Magomet Farman ogly Mekhtiyev, Yagub A. Sharifov   +2 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Boundary-value problems with integral conditions for a system of Lame equations in the space of almost periodic functions

Electronic Journal of Differential Equations, 2016
We study a problem with integral boundary conditions in the time coordinate for a system of Lame equations of dynamic elasticity theory of an arbitrary dimension.
Volodymyr S. Il'kiv, Zinovii M. Nytrebych, Petro Ya. Pukach   +2 more
doaj