Results 131 to 140 of about 4,987,876 (357)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Investigating the Feasibility and Stability for Modeling Acoustic Wave Scattering Using a Time-Domain Boundary Integral Equation with Impedance Boundary Condition

, 2020
Michelle E. Rodio
openalex   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Monotone iterative and quasilinearization method for a nonlinear integral impulsive differential equation

AIMS Mathematics
In this paper, we discuss the existence and approximation of solution sequences for a class of nonlinear ordinary differential equations with an impulsive integral condition. Our major methods were the monotone iterative and quasilinearization techniques.
Yan Li, Zihan Rui, Bing Hu
semanticscholar   +1 more source

Hypoelastic's integrability condition

Geometric reformulation of hypoelasticity and novel necessary condition for the integrability into an elastic law.
Lloria, Romain, Desmorat, Rodrigue, Kolev, Boris   +2 more
openaire   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

On the existence of positive solutions for a local fractional boundary value problem with an integral boundary condition

, 2020
Asghar Ahmadkhanlu
openalex   +2 more sources

A necessary condition for an extremum of a double integral [PDF]

, 1907
Max Mason
openalex   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The eigenfrequencies of spheroids obtained from an integral phase matching condition [PDF]

, 1986
Barbara L. Merchant, Y. J. Stoyanov, A. Nagl, H. Überall, Susan Brown, J. Dickey   +5 more
openalex   +1 more source