Results 81 to 90 of about 83,871 (280)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Existence theorems for completely non convex problems

Le Matematiche, 1986
In this note we give some existence theorems for integral functionals with non convex integrand. We consider first the simpler case in which minimization is taken on decomposable spaces and successively we prove an existence theorem also for the minimum ...
Ottavio Caligaris
doaj  

Spatio-temporal tensor-network approaches to out-of-equilibrium dynamics bridging open and closed systems

Frontiers in Quantum Science and Technology
The study of many-body quantum systems out of equilibrium remains a significant challenge, with complexity barriers arising in both state- and operator-based representations.
Sergio Cerezo-Roquebrún, Aleix Bou-Comas, Jan T. Schneider, Esperanza López, Luca Tagliacozzo, Stefano Carignano   +5 more
doaj   +1 more source

Naturally integrable functions [PDF]

Pacific Journal of Mathematics, 1980
Dubins, Lester E., Margolies, David
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Accuracy of discrete approximation for integral functionals of Markov processes

Modern Stochastics: Theory and Applications, 2015
The article is devoted to the estimation of the convergence rate of integral functionals of a Markov process. Under the assumption that the given Markov process admits a transition probability density differentiable in t and the derivative has an ...
Iurii Ganychenko, Victoria Knopova, Alexei Kulik   +2 more
doaj   +1 more source

On Functions of Integrals [PDF]

Proceedings of the Edinburgh Mathematical Society, 1932
The object of this paper is to discuss conditions for a maximum or minimum of functions of integrals of the typeemploying the methods of the Calculus of Variations.
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source