Results 111 to 120 of about 721,077 (354)

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira   +14 more
wiley   +1 more source

Grothendieck groups of integral nilpotent group rings

open access: yesJournal of Algebra, 1984
Let R be a Dedekind domain, G a finite group, RG the group ring of G over R and \(G_ 0(RG)\) the Grothendieck group of the category of finitely generated RG-modules. The purpose of this paper is to generalize \textit{H. Lenstra}'s [J. Pure Appl. Algebra 20, 173-193 (1981; Zbl 0467.16016)] calculation of \(G_ 0(RG)\) from abelian groups G to nilpotent ...
openaire   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

open access: yesMolecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian   +10 more
wiley   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

The role of hydroxyindoles in protecting neuronal cultures from ferroptosis

open access: yesCell Death Discovery
Hydroxyindoles are organic compounds characterized by a hydroxyl group attached to an indole ring. One notable example is 5-hydroxyindole, which can be found in humans, plants, and microorganisms. The structure of 5-hydroxyindole is integral to molecules
Md. Jakaria, Jason R. Cannon
doaj   +1 more source

Finite groups in integral group rings

open access: yes, 2018
Notes used for a course held in 2016 in the School of Advances in Group Theory and Applications, for some lectures given in 2018 for the students of the Master in Mathematics of the Vrije Universiteit Brussels, a course for master and Ph.D. students at the Universidade de São Paulo and at the conference Group algebras, representations and computations.
openaire   +2 more sources

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

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