Results 141 to 150 of about 2,996,093 (304)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Effect of Mismatch of Elemental Image Array on Integral Imaging 3D Display

工程科学与技术, 2017
:Integral imaging is one of the most popular three-dimensional (3D) display technologies,since it has many advantages,such as naked-eye watching, no obvious visual fatigue and truly reconstruction of 3D image.During the assembly process of the integral ...
邓慧, 吴非, 邓欢
doaj  

Optically anisotropic, electrically tunable microlens arrays formed via single-step photopolymerization-induced phase separation in polymer/liquid-crystal composite materials

Light: Advanced Manufacturing
Microlenses or arrays are key elements in many applications. However, their construction methods involve multiple fabrication processes, thereby increasing the complexity and cost of fabrication.
Wenfeng Cai, Delai Kong, Zongjun Ma, Mengjia Cen, Jiawei Wang, Dandan Yuan, Ke Li, Ming Cheng, Shaolin Xu, Dan Luo, Yanqing Lu, Yanjun Liu   +11 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Plan de Gestión Integral de Residuos Sólidos (PGIRS)

, 2016
La Alcaldía de Medellín y la Universidad de Medellín realizan la Actualización del Plan de Gestión Integral de Residuos Sólidos- PGIRS para la ciudad de Medellín y sus 5 corregimientos.
Plan de Gestión Integral de Residuos Sólidos (PGIRS)
core  

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Position detection of component aperture based on integral imaging technology

Journal of Measurement Science and Instrumentation, 2017
Aiming at the problem that it is difficult to locate all the aperture positions of the large size component using Hough circle detection method,this article presents a non-contact measurement method combining the integral imaging technology with Hough ...
ZHANG Xiao-dong, WU Bin, YANG Zhi-yuan
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The Integral Trees with Spectral Radius 3 [PDF]

There are eleven integral trees with largest eigenvalue 3.Integral graphs;graph spectra ...
Brouwer, A.E., Haemers, W.H.
core  

Advances in crosshole seismic reflection processing [PDF]

, 1993
In recent years there have been significant advances in the acquisition and processing of crosshole seismic reflection data, and the method has been shown to be a high resolution imaging technique.
Rowbotham, Peter S
core