Results 111 to 120 of about 1,708,072 (297)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Contaminación y riesgos por desechos metálicos en Santo Domingo [PDF]

open access: yes, 2019
José Ramón Peña Diaz, Físico Teórico, especializado en Gestión de Riesgo Sísmico, Educación Ambiental y Derecho Energético. Coordinador del equipo de expertos CDEEE para la elaboración del plan institucional para la Gestión Integral ante riesgos de ...
Peña Díaz, José Ramón.
core  

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Evaluación del efecto del Plan de Salud Oral de embarazadas en sus hijos en Lo Barnechea, Chile

open access: yesOdontoestomatología
Objetivo. El propósito de este estudio fue evaluar el efecto educativo del Plan de Salud Oral Integral de la Embarazada, aplicado desde el año 2010 en Chile, sobre la salud oral de sus hijos a los dos años de edad en el centro de salud familiar (CESFAM ...
Consuelo Riadi-Cornejo   +3 more
doaj  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Propuesta de plan de gestión integral de residuos sólidos, sector de los puentes en la comuna 3 del municipio de Tumaco Nariño [PDF]

open access: yes, 2016
Una de las problemáticas que enfrentan los grandes y pequeños centros poblados es el manejo y disposición final de los residuos sólidos resultado de las actividades antrópicas. El sector de los puentes en la comuna 3 del municipio de Tumaco presenta unas
Bastidas Vergara, José Miguel   +1 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The Presence of Ethics in Initial Teacher Training: Reasons and Implications

open access: yesEducation Sciences
Ethics has emerged as a central dimension of the teaching profession, although it is not always explicitly addressed in initial teacher training study plans.
Evangelina Bonifácio   +2 more
doaj   +1 more source

Saving our species [PDF]

open access: yes
Science is vital to our conservation management. Our ecologists work hand-in-hand with land managers to plan and deliver effective conservation management for Australia’s species.
Jim Radford
core  

Home - About - Disclaimer - Privacy