Results 111 to 120 of about 552,366 (332)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Integral Representation Theorems [PDF]

open access: yes, 1971
Since F. Riesz showed in 1909 that the dual of C[0, 1] is BV[0, 1] (the functions of bounded variation on [0, 1] with II g IIBV = V(g)) via the Stieltjes integral, obtaining representations for linear operators in various settings has been a problem of interest.
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

The Real and Complex Techniques in Harmonic Analysis from the Point of View of Covariant Transform

open access: yes, 2014
This note reviews complex and real techniques in harmonic analysis. We describe a common source of both approaches rooted in the covariant transform generated by the affine group.
Kisil, Vladimir V.
core  

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

A Note on the Integral Representation of Some Relative Growth Indicators of Entire Algebroidal Functions

open access: yesJournal of New Theory, 2018
Let p and q be any two positive integers. In this paper the concept of tworelative growth indicators namely relative (p, q)-th type and relative (p, q)-th weak type of entirefunctions with respect to entire algebroidal functions have been introduced from
Sanjib Kumar Datta, Aditi Biswas
doaj  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

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