Results 111 to 120 of about 423 (186)

Local Polynomial Regression and Filtering for a Versatile Mesh‐Free PDE Solver

open access: yesInternational Journal for Numerical Methods in Fluids, Volume 98, Issue 7, Page 804-839, July 2026.
A high‐order, mesh‐free finite difference method for solving differential equations is presented. Both derivative approximation and scheme stabilisation is carried out by parametric or non‐parametric local polynomial regression, making the resulting numerical method accurate, simple and versatile. Numerous numerical benchmark tests are investigated for
Alberto M. Gambaruto
wiley   +1 more source

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

open access: yesMedicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur   +6 more
wiley   +1 more source

Stability of a Fully Discrete Local Discontinuous Galerkin Method for the Generalized Benjamin–Ono Equation

open access: yesNumerical Methods for Partial Differential Equations, Volume 42, Issue 4, July 2026.
ABSTRACT The main purpose of this paper is to design a fully discrete local discontinuous Galerkin (LDG) scheme for the generalized Benjamin–Ono equation. First, we prove the L2$$ {L}^2 $$‐stability for the proposed semi‐discrete LDG scheme and obtained a suboptimal order of convergence for power nonlinear flux.
Mukul Dwivedi, Tanmay Sarkar
wiley   +1 more source

Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans

open access: yesThe FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Microgravity (μG) reduces mechanical tactile stimulation in Caenorhabditis elegans, causing neuromuscular decline, altered gene expression, synaptic defects, and accelerated aging phenotypes. The gentle‐touch mechanoreceptor MEC‐4 mediates μG‐induced body length reduction and extracellular matrix gene downregulation.
Atsushi Higashitani   +16 more
wiley   +1 more source

Thermodynamics‐Based THMC Model for Solute Transport in Sorptive Fractured Rock: Coupling Multi‐Phase Flow, Heat, and Deformation

open access: yesGeophysical Research Letters, Volume 53, Issue 11, 16 June 2026.
Abstract Fractured porous rocks host a complex interplay of heat, fluids, deformation, and chemical reactions, yet their combined influence on solute transport remains poorly resolved. Here we show that these processes are more tightly coupled than previously assumed.
Kai Wang   +6 more
wiley   +1 more source

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