Results 141 to 150 of about 7,950,423 (253)

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Long-Range Charge Transfer (LRCT)-Driven Enhancement of SOC and rISC in Donor-Modified MR-TADF Emitters. [PDF]

J Chem Theory Comput
Wen H, Ungur L.
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Observable Classification Patterns and Diagnostic Uncertainty in Parotid Ultrasound: A Multimethod Secondary Analysis. [PDF]

Diagnostics (Basel)
Pillong L, Walzer O, Peters M, Ohnesorg I, Palm J, Bozzato V, Garner M, Schick B, Bozzato A, Jäger T, Müller A, Pulham S, Voges M.   +12 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Structural Evolution of RAFT-Modified Unsaturated Polyester Copolymers: Effects of CPDT Concentration, Acidic Comonomer Structure, and Polyester Matrix Architecture. [PDF]

Molecules
Zhunissova MS, Sarsenbekova AZ, Takibayeva AT, Khamitova TO, Zhaxybayeva A, Kaliyeva S, Kuderina B, Musina GN, Bussurmanova A.   +8 more
europepmc   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

From Chemical Scaffold to Predicted Toxicity: A Scaffold-Aware Pipeline for Reliable In Silico Prioritization of <i>Heracleum</i> Furanocoumarins. [PDF]

Int J Mol Sci
Rassabina AE, Safronov VS, Fedorov MV.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Descriptor-driven design of carbon nitride for visible light photocatalysis

Photocatalysis utilizing carbon nitride (CN) based photocatalysts presents an eco-friendly solution to energy challenges. Despite progress in enhancing CN performance, targeted design for specific applications remains challenging due to the complex ...
Haoxin Mai (18032953), Kazunari Domen (1294314), Dehong Chen (1766056), Junlin Lu (8454807), Takashi Hisatomi (1427668), Nicholas Cox (1498486), Edwin LH Mayes (14864605), Xiaoming Wen (18039340), Xuying Li (18035389), Rachel Caruso (18026611), Qi Li (67548), Salvy Russo (18029545), Tsuyoshi Takata (1510555)   +12 more
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