Results 111 to 120 of about 4,021,217 (356)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

Introduction of New General Laplace-Type Integral Transform: The Iyeme-Okpo Transform

open access: yesJournal of Applied Sciences and Environmental Management
In this paper, a new general Laplace-type integral transform called Iyeme-Okpo transform that generalizes all the existing Laplace-type integral transforms has been introduced. Thus, existing integral transforms such as Laplace, Sumudu, Natural, Jafari,
E. E. Iyeme, O. R. Okpo
doaj  

A new integral transform with an application in heat-transfer problem

open access: yes, 2016
In this paper, an new integral transform J[Φ(τ)] =1/μ ∫0∞Φ(τ)e−μτ dτ is proposed for the first time. The integral transform is used to solve the differential equation arising in heat-transfer problem.
Xiao-jun Yang
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

\(L_p\)-boundedness of the Laplace transform

open access: yesCubo
In this paper, we discuss about the boundedness of the Laplace transform \(\mathcal{L}: L_p([0,\infty))\rightarrow L_p(A)\) (\(p\geq1\)) for the cases \(A=[0, \infty)\), \(A=[1, \infty)\) and \(A=[0, 1]\).
René Erlín Castillo   +2 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Impedance Spectrum Measurement and Fault Detection for XLPE Coaxial Cables

open access: yesJournal of Harbin University of Science and Technology
XLPE coaxial cables are prone to faults and defects in the process of power transmission, seriously jeopardizing the safe operation of the power system. The limitations of the existing fault diagnosis methods are analyzed, and a new method is proposed
LIU Chunqi   +3 more
doaj   +1 more source

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