Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
A novel method for approximate solution of two point non local fractional order coupled boundary value problems. [PDF]
Tadoummant L +4 more
europepmc +1 more source
Glymphatic Dysfunction Reflects Post‐Concussion Symptoms: Changes Within 1 Month and After 3 Months
ABSTRACT Objective Mild traumatic brain injury (mTBI) may alter glymphatic function; however, its progression and variability remain obscure. This study examined glymphatic function following mTBI within 1 month and after 3 months post‐injury to determine whether variations in glymphatic function are associated with post‐traumatic symptom severity ...
Eunkyung Kim +3 more
wiley +1 more source
A plastic analysis of Griffith crack problem in 1D hexagonal piezoelectric quasicrystals. [PDF]
Zhang J, Liu G, Liao H.
europepmc +1 more source
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu +11 more
wiley +1 more source
Revisiting the inverse Abel integral for reconstructing velocity-map images.
Sparling C, Onvlee J.
europepmc +1 more source
Including Quantum Effects in Molecular Simulations Using the Feynman-Kleinert Linearized Path Integral Method. [PDF]
Poulsen JA, Nyman G.
europepmc +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Multivariate Frequency and Amplitude Estimation for Unevenly Sampled Data Using and Extending the Lomb-Scargle Method. [PDF]
Seilmayer M, Wondrak T, Garcia F.
europepmc +1 more source

