Results 71 to 80 of about 2,172 (215)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Introduction of New General Laplace-Type Integral Transform: The Iyeme-Okpo Transform

Journal of Applied Sciences and Environmental Management
In this paper, a new general Laplace-type integral transform called Iyeme-Okpo transform that generalizes all the existing Laplace-type integral transforms has been introduced. Thus, existing integral transforms such as Laplace, Sumudu, Natural, Jafari,
E. E. Iyeme, O. R. Okpo
doaj  

On one generalization of Bessel function

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2014
In this paper the generalized Bessel function $J_{\mu ,\omega } ( x )$ is introduced. The function $J_{\mu ,\omega } ( x )$ is given as one solution of the following differential equation: $$ x^2{y}''+x{y}'+\left( {x-\mu ^2} \right)\left( {x+\omega ^2 ...
Nina A Virchenko, Maria O Chetvertak
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

\(L_p\)-boundedness of the Laplace transform

Cubo
In this paper, we discuss about the boundedness of the Laplace transform \(\mathcal{L}: L_p([0,\infty))\rightarrow L_p(A)\) (\(p\geq1\)) for the cases \(A=[0, \infty)\), \(A=[1, \infty)\) and \(A=[0, 1]\).
René Erlín Castillo, Héctor Camilo Chaparro, Julio César Ramos-Fernández   +2 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Impedance Spectrum Measurement and Fault Detection for XLPE Coaxial Cables

Journal of Harbin University of Science and Technology
XLPE coaxial cables are prone to faults and defects in the process of power transmission, seriously jeopardizing the safe operation of the power system. The limitations of the existing fault diagnosis methods are analyzed, and a new method is proposed
LIU Chunqi, LI Shufeng, HUANG Yu, CHEN Dongsheng   +3 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

A Semi-Analytical Solution of Two-Dimensional Unsteady Groundwater Flow Outside a Long-Strip Excavation Pit with a Cut-Off Wall

Applied Sciences
In deep excavation engineering, the implementation of cut-off walls stands as a crucial measure to ensure structural support stability. However, the existing theories for dewatering design often overlook the variations in cut-off wall penetration depths,
Yinsheng Chang, Le Lv, Xudong Wang, Jin Xu   +3 more
doaj   +1 more source