Results 101 to 110 of about 4,172 (287)
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Fractional calculus of periodic distributions [PDF]
, 2011 Two approaches for defining fractional derivatives of periodic distributions are presented. The first is a distributional version of the Weyl fractional derivative in which a derivative of arbitrary order of a periodic distribution is defined via Fourier
Lamb, Wilson +5 more
core +1 more source
Researches in MathematicsThis research article explores some new properties of generalized hypergeometric function and its q-analogue. The connections between ${}_{2}{{R}_{1}}^{\upsilon }(\mathfrak{z})$, the Wright function, and generalized Mittag-Leffler functions are explored.
K.K. Chaudhary, S.B. Rao
doaj +1 more source
Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer
Aging and Cancer, EarlyView.Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss +12 more
wiley +1 more source
Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level
Aging and Cancer, EarlyView.This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley +1 more source
INTEGRAL TRANSFORMS WITH THE HOMOTOPY PERTURBATION METHOD AND SOME APPLICATIONS [PDF]
This paper applies He's homotopy perturbation method to compute a large variety of integral transforms. As illustration, the paper gives special attention to the Esscher transform, the Fourier transform, the Hankel transform, the Mellin transform, the ...
Jules Sadefo Kamdem
core
The lagrange polynomials in several variables [PDF]
, 2010 The authors introduce (and investigate vgarious peoperties and characteristics of) a multi-variable extension of the familiar Lagrange polynomials which are known to occur in certain problems in statistics.
Chan, Whei-ching; Chyan, C. J.; Srivastava, H. M.
core +1 more source
A Wright-Based Generalization of the Euler Beta Function with Statistical Applications
MathematicsIn recent years, special function theory has played an increasingly important role in the development of advanced mathematical models and statistical distributions.
Layth T. Khudhuir +3 more
doaj +1 more source
New Directions for Adult and Continuing Education, EarlyView.ABSTRACT Mental well‐being is central to adult learner success, yet many adult education institutions lack capacity to provide timely and accessible support. This article examines how artificial intelligence (AI) can strengthen mental health–adjacent supports in adult and continuing higher education, with attention to professional practice and ...
Adam L. McClain, Thomas Wade
wiley +1 more source