Results 201 to 210 of about 85,046 (318)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Exact Quadrature of Singular and Nearly Singular Potential Integrals [PDF]

, 2007
R.D. Graglia, GRAGLIA, Roberto, Graglia R.D, G. Lombardi, Lombardi, Guido   +4 more
core   +1 more source

Mechanistic Analysis of Large Atomic Models of Molten Salt. [PDF]

Adv Sci (Weinh)
Guo Y, Sun X, Xi X, Nie Z.
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Accurate evaluation of potential integrals with Gauss quadrature formulas for rational functions [PDF]

, 2007
Graglia, Roberto, Guido Lombardi, Roberto D. Graglia, Lombardi, Guido   +3 more
core   +1 more source

Revealing Hidden Dynamics of Hydrogel-Based Desalination with ²³Na Nuclear Magnetic Resonance. [PDF]

J Phys Chem C Nanomater Interfaces
Zou H, Zhang C, Teleanu F, Jangizehi A, Seiffert S, Jerschow A.   +5 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

A Universal Framework for Blood Ionome Extraction and Intelligent Quality Control in ¹H NMR Metabolomics. [PDF]

Anal Chem
Theodorou A, Vučković I, Papadimitriou E, Papakonstantinou K, Taki V, Louka A, Papaloukas C, Stalikas CD, Giormezis N, Paliogianni F, Lanza IR, Stebbing J, Takis PG.   +12 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Quantitative Enhancement of Spectral Imaging in Photon-Counting CT via Dynamic Energy Thresholding. [PDF]

Proc SPIE Int Soc Opt Eng
Lee D, Jiang X, Stayman JW, Gang GJ.
europepmc   +1 more source